Pancreatic adenocarcinoma: imaging techniques for diagnosis and management
Farrukh, Jawaad Balasubramaniam, Ravivarma James, Anitha Wadhwani, Sharan S Albazaz, Raneem
Farrukh, Jawaad
Balasubramaniam, Ravivarma
James, Anitha
Wadhwani, Sharan S
Albazaz, Raneem
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Affiliation
Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust; University Hospitals of North Midlands NHS Trust; The Leeds Teaching Hospitals NHS Trust
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Publication date
2022-05-27
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Abstract
Pancreatic cancer is a leading cause of death from cancer but only a minority of patients with pancreatic ductal adenocarcinomas are eligible for curative resection. The increasing role of neoadjuvant therapy provides hope of improving outcomes. However, progress is also reliant on advances in imaging that can identify disease earlier and accurately assess treatment response. Computed tomography remains the cornerstone in evaluation of resectability, offering excellent spatial resolution. However, in high-risk patients, additional magnetic resonance imaging and positron emission tomography-computed tomography may further guide treatment decisions. Conventional computed tomography can be limited in its ability to determine disease response after neoadjuvant therapy. Dual-energy computed tomography and computed tomography or magnetic resonance imaging perfusion studies emerging as potentially better alternatives. Combined with pioneering advances in radiomic analysis, these modalities also show promise in analysing tumour heterogeneity and thereby more accurately predicting outcomes. This article reviews these imaging techniques.
Citation
Farrukh J, Balasubramaniam R, James A, Wadhwani SS, Albazaz R. Pancreatic adenocarcinoma: imaging techniques for diagnosis and management. Br J Hosp Med (Lond). 2022 May 2;83(5):1-12. doi: 10.12968/hmed.2022.0065. Epub 2022 May 27.
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Article