A rare case of Cold Antibody-mediated Autoimmune Haemolytic Anaemia in early Systemic Lupus Erythematosus
Rajaram, Harisanth Ganegoda, Sherwin Andev, Rajinder
Rajaram, Harisanth
Ganegoda, Sherwin
Andev, Rajinder
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Affiliation
Royal Berkshire NHS Foundation Trust; Oxford University Hospitals NHS Foundation Trust; Sandwell and West Birmingham NHS Trust
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Publication date
2025-06-27
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Abstract
Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterised by autoantibody production, leading to multiorgan inflammation and tissue damage. Autoimmune haemolytic anaemia (AIHA) is a recognised haematologic complication of SLE. This report describes a 16-year-old female who presented with four weeks of generalised weakness, polyarthralgia, recurrent syncopal episodes, and Raynaud's phenomenon. This case highlights the diagnostic challenges of SLE presenting with AIHA, underscoring the importance of prompt, comprehensive autoimmune and haematologic evaluation in adolescents with unexplained anaemia and multi-system involvement.
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Rajaram H, Ganegoda S, Andev R. A Rare Case of Cold Antibody-Mediated Autoimmune Haemolytic Anaemia in Early Systemic Lupus Erythematosus. Cureus. 2025 Jun 27;17(6):e86842. doi: 10.7759/cureus.86842
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Article