Challenges of conducting clinical trials during the SARS-CoV-2 pandemic: the ASCEND global program experience.
Johansen, Kirsten L Acharya, Anjali Cizman, Borut Cobitz, Alexander R Correa-Rotter, Ricardo Dasgupta, Indranil Kher, Vijay Lopes, Renato D Matsumoto, Leonardo Meadowcroft, Amy M
Johansen, Kirsten L
Acharya, Anjali
Cizman, Borut
Cobitz, Alexander R
Correa-Rotter, Ricardo
Dasgupta, Indranil
Kher, Vijay
Lopes, Renato D
Matsumoto, Leonardo
Meadowcroft, Amy M
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2022-02-10
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The coronavirus disease 2019 pandemic has had an unprecedented effect on health and health care and posed challenges to the conduct of clinical trials.Targeted mitigating strategies, on the basis of early and continued data collection from site surveys, limited disruption to the ASCEND trials.Flexibly allowing hemoglobin assessment at local laboratories to inform randomized treatment dosing was key to limiting the discontinuation of treatment.
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Johansen KL, Acharya A, Cizman B, Cobitz AR, Correa-Rotter R, Dasgupta I, Kher V, Lopes RD, Matsumoto L, Meadowcroft AM, Merege Vieira Neto O, Okabe M, Rayner B, Silva A, Thomas H, Singh AK. Challenges of Conducting Clinical Trials during the SARS-CoV-2 Pandemic: The ASCEND Global Program Experience. Kidney360. 2022 Feb 10;3(4):728-733. doi: 10.34067/KID.0006212021
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