Propranolol ameliorates the antifungal activity of azoles in invasive candidiasis
Mayandi, Venkatesh Kang, Wen-Tyng Ting, Darren Shu Jeng Goh, Eunice Tze Leng Lynn, Myoe Naing Aung, Thet Tun Vadivelu, Jamuna Barathi, Veluchamy Amutha Chan, Anita Sook Yee Lakshminarayanan, Rajamani
Mayandi, Venkatesh
Kang, Wen-Tyng
Ting, Darren Shu Jeng
Goh, Eunice Tze Leng
Lynn, Myoe Naing
Aung, Thet Tun
Vadivelu, Jamuna
Barathi, Veluchamy Amutha
Chan, Anita Sook Yee
Lakshminarayanan, Rajamani
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Affiliation
Singapore Eye Research Institute; Duke-NUS Graduate Medical School; University of Malaya; Sandwell and West Birmingham NHS Trust; et al.
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Publication date
2023-03-23
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Abstract
The effectiveness of current antifungal therapies is hampered by the emergence of drug resistance strains, highlighting an urgent need for new alternatives such as adjuvant antifungal treatments. This study aims to examine the synergism between propranolol and antifungal drugs, based on the premise that propranolol is known to inhibit fungal hyphae. In vitro studies demonstrate that propranolol potentiates the antifungal activity of azoles and that the effect is more pronounced for propranolol-itraconazole combination. Using an in vivo murine systemic candidemia model, we show that propranolol-itraconazole combination treatment resulted in a lower rate of body weight loss, decreased kidney fungal bioburden and renal inflammation when compared to propranolol and azole treatment alone or untreated control. Altogether, our findings suggest that propranolol increases the efficacy of azoles against C. albicans, offering a new therapeutic strategy against invasive fungal infections.
Citation
Mayandi V, Kang WT, Ting DSJ, Goh ETL, Lynn MN, Aung TT, Vadivelu J, Barathi VA, Chan ASY, Lakshminarayanan R. Propranolol Ameliorates the Antifungal Activity of Azoles in Invasive Candidiasis. Pharmaceutics. 2023 Mar 23;15(4):1044. doi: 10.3390/pharmaceutics15041044
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Article