The 2025 British Society for Rheumatology management recommendations for ANCA-associated vasculitis
Biddle, Kathryn Jade, Judith Wilson-Morkeh, Harold Adikari, Madura Yaghchi, Chadwan Al Anastasa, Zoi Basu, Neil Brogan, Paul Chanouzas, Dimitrios Dass, Shouvik
Biddle, Kathryn
Jade, Judith
Wilson-Morkeh, Harold
Adikari, Madura
Yaghchi, Chadwan Al
Anastasa, Zoi
Basu, Neil
Brogan, Paul
Chanouzas, Dimitrios
Dass, Shouvik
Affiliation
Guy's and St Thomas' NHS Foundation Trust; Sheffield Teaching Hospitals NHS Foundation Trust; Imperial College Healthcare NHS Trust; Imperial College London; Royal Chesterfield NHS Foundation Trust; Expert by Experience; University of Glasgow; Great Ormond Street Hospital NHS Foundation Trust; University College London; University Hospitals Birmingham NHS Foundation Trust; University of Birmingham; Leeds Teaching Hospitals NHS Trust; Cambridge University Hospital; Royal Wolverhampton NHS Trust; Norfolk and Norwich University Hospital; University Hospital of Wales; University of Aberdeen; NHS Grampian; West Suffolk Hospital; University Hospital Southampton; Liverpool University Hospitals NHS Foundation Trust; Staffordshire University; East Suffolk and North Essex NHS Foundation Trust; University of Nottingham; Royal Free Hospital; Royal Brompton and Hammersmith Hospitals; University of Cambridge
Other Contributors
Joyce, Christopher
McLaren, Zoe
Jones, Claire
Merrison, Karen
Roddy, Edward
Saha, Pratyasha
Williams, Emma
Rose-Parfitt, Emily
Mewar, Devesh
Cotton, Caroline
Compeyrot-Lacassagne, Sandrine
Kuttikat, Anoop
Jayasekera, Hirushi
Ciurtin, Coziana
McLaren, Zoe
Jones, Claire
Merrison, Karen
Roddy, Edward
Saha, Pratyasha
Williams, Emma
Rose-Parfitt, Emily
Mewar, Devesh
Cotton, Caroline
Compeyrot-Lacassagne, Sandrine
Kuttikat, Anoop
Jayasekera, Hirushi
Ciurtin, Coziana
Publication date
2025-06-12
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Research Projects
Organizational Units
Journal Issue
Abstract
ANCA-associated vasculitis (AAV) is comprised of three specific conditions: granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA). Since the publication of the last British Society for Rheumatology (BSR) and British Health Professionals in Rheumatology (BHPR) guideline for the management of adults with AAV in 2014, a plethora of randomized controlled trials, additional research and recommendations have provided novel insights into how the management of AAV can be optimized, thus improving patient quality of life. The BSR AAV Working Group (WG) reviewed published guidelines, undertook a systematic literature review and utilized expertise from specialist vasculitis centres across the UK and patient representatives to formulate a list of 26 recommendations with corresponding strength of agreement (SOA) scores. Recommendations were updated from the published 2014 BSR and BHPR guideline. The 26 recommendations encompassed five key domains: 1. Treatment for GPA and MPA; 2. Management of subglottic stenosis and ear, nose and throat (ENT) manifestations of AAV; 3. Management and treatment for EGPA; 4. Service specifications; 5. Patient education and support. These recommendations provide an update on care delivery of AAV based on current evidence and specialist opinion. In addition, we have provided research and audit recommendations to support equitable access to care and improve health outcomes. The lay summary that accompanies this abstract can be found in Supplementary Data S1, available at Rheumatology online.
Citation
Biddle K, Jade J, Wilson-Morkeh H, Adikari M, Yaghchi CA, Anastasa Z, Basu N, Brogan P, Chanouzas D, Dass S, D'Cruz D, Del Pero MM, Dhillon E, Ducker G, Griffin S, Hollick RJ, Jackson D, King C, Marlais M, Mason A, McAdoo S, Mewar D, Mooney J, Ntatsaki E, Pearce F, Rhodes B, Rupani H, Salama A, Siddiqui S, Smith R, Harper L; British Society for Rheumatology Guideline Steering Group. The 2025 British Society for Rheumatology management recommendations for ANCA-associated vasculitis. Rheumatology (Oxford). 2025 Aug 1;64(8):4470-4494. doi: 10.1093/rheumatology/keaf240.
Type
Article