The neuropsychiatric effects of nitrous oxide and low vitamin B12
Romain, Karen Ibrahim, Mina Kumar, Manoj Therayil Moore, William York
Romain, Karen
Ibrahim, Mina
Kumar, Manoj Therayil
Moore, William York
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Affiliation
Coventry and Warwickshire Partnership Trust; Institute for Mind & Brain, Kerala, India; Herefordshire Mental Health and Learning Disability Services
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Publication date
2021-09-30
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Abstract
This narrative review article aims to update knowledge on the neuropsychiatric complications of nitrous oxide use and low vitamin B12. We consider common forms and uses of nitrous oxide (N2O) and review its mechanism of action, and then explore the potential impacts of use. In particular, neuropsychiatric effects mediated by low vitamin B12 are considered and the correct interpretation of laboratory results explored. This is of particular importance as where vitamin B12 is inactivated by chronic nitrous oxide use, blood test levels of vitamin B12 may not reflect the quantity of functional B12 in patients.
Citation
Farmer J, Romain K, Ibrahim M, Kumar M, York Moore W. The neuropsychiatric effects of nitrous oxide and low vitamin B12. BJPsych Advances. 2022;28(4):216-225. doi:10.1192/bja.2021.55
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Article