Functionality loss due to COVID-19 hospitalisation in older adults recovers with inpatient rehabilitation: A systematic review and meta-analysis
Lapo, Henrique Monteiro Sardeli, Amanda Veiga Mariano, Lilian Oliveira Howroyd, Fiona Jayne Sokoll, Paulo Roberto Sapey, Elizabeth Chacon-Mikahil, Mara Patrícia Traina
Lapo, Henrique Monteiro
Sardeli, Amanda Veiga
Mariano, Lilian Oliveira
Howroyd, Fiona Jayne
Sokoll, Paulo Roberto
Sapey, Elizabeth
Chacon-Mikahil, Mara Patrícia Traina
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Affiliation
University of Campinas (UNICAMP); University of Birmingham; University Hospitals Birmingham NHS Foundation Trust; Health department of Ludwigsburg
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Publication date
2024-11-05
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Abstract
Introduction: Older adults are more likely to acquire the severe manifestation of COVID-19 and the hospitalised survivors experience significant functionality loss. Thus, we aimed to identify the level of functionality in older adults hospitalised due to COVID-19, and the effect of inpatient rehabilitation upon functional recovery.
Methods: A search was performed on July 2024, across five databases to retrieve studies assessing functionality in patients during COVID-19 hospitalisation, with or without rehabilitation.
Results: At admission, higher functionality was significant higher for survivors than non survivors (standardized mean difference (SMD): 0.83 [0.56; 1.09]). The effect of inpatient rehabilitation on functionality was tested among 38 arms across studies. Inpatient rehabilitation improved functionality SMD across all indexes (1.47 [1.18; 1.77], P ≤ 0.001), with greatest effect in the patients >70y (2.84 [1.74, 3.93], P = 0.006), compared to their counterparts.
Conclusion: Hospitalisation due to COVID-19 reduced functionality to a higher extent in older adults above 70 years. Inpatient rehabilitation was effective to improve functionality in both age groups.
Protocol registration: PROSPERO CRD42021278619.
Citation
Lapo HM, Sardeli AV, Mariano LO, Howroyd FJ, Sokoll PR, Sapey E, Chacon-Mikahil MPT. Functionality loss due to COVID-19 hospitalisation in older adults recovers with inpatient rehabilitation: A systematic review and meta-analysis. Exp Gerontol. 2024 Dec;198:112617. doi: 10.1016/j.exger.2024.112617.
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Article