Extramedullary chronic phase chronic myeloid leukaemia (CML) involving the central nervous system: A case report
Deshpande, Akshay Osman, Dina Murthy, Vidhya Hussein, Hayder
Deshpande, Akshay
Osman, Dina
Murthy, Vidhya
Hussein, Hayder
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University Hospitals Birmingham NHS Foundation Trust
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Publication date
2024-06-25
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Abstract
Chronic myeloid leukaemia (CML) has been classically described as a disease restricted to the bone marrow with very few reports of extramedullary involvement. CNS involvement with CML has been described in the literature as an aggressive disease in the leukaemic phase either preceding or coexisting with medullary blast crisis or seen in patients with long-term Imatinib therapy. No treatment consensus exists for this patient group and outcomes remain poor. We hereby present a very rare report of CNS involvement with chronic phase CML at diagnosis in a patient who presented with raised intracranial pressure and cranial nerve palsies.
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Deshpande A, Osman D, Murthy V, Hussein H. Extramedullary chronic phase chronic myeloid leukaemia (CML) involving the central nervous system: A case report. EJHaem. 2024 Jun 25;5(4):859-862. doi: 10.1002/jha2.967.
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Report