Skull base surgery for malignant tumors: The 2nd international collaborative study (1995-2015).
Shah, Jatin P Levyn, Helena Valero, Cristina Adilbay, Dauren Eagan, Alana Zheng, Junting Gonen, Mithat Cohen, Marc Patel, Snehal Ganly, Ian
Shah, Jatin P
Levyn, Helena
Valero, Cristina
Adilbay, Dauren
Eagan, Alana
Zheng, Junting
Gonen, Mithat
Cohen, Marc
Patel, Snehal
Ganly, Ian
Citations
Altmetric:
Affiliation
Other Contributors
Publication date
2024-05-21
Subject
Collections
Research Projects
Organizational Units
Journal Issue
Abstract
Background: The current study presents the effort of a global collaborative group to review the management and outcomes of malignant tumors of the skull base worldwide.
Patients and methods: A total of 28 institutions contributed data on 3061 patients. Analysis evaluated clinical variables, survival outcomes, and multivariable factors associated with outcomes.
Results: The median age was 56 years (IQR 44-67). The open surgical approach was used in 55% (n = 1680) of cases, endoscopic resection was performed in 36% (n = 1087), and the combined approach in 9.6% (n = 294). With a median follow-up of 7.1 years, the 5-year OS DSS and RFS were 65%, 71.7% and 53%, respectively. On multivariable analysis, older age, comorbidities, histology, dural/intracranial involvement, positive margins, advanced stage, and primary site were independent prognostic factors for OS, DSS, and RFS. Adjuvant RT was a protective prognostic factor.
Conclusion: The progress across various disciplines may have contributed to improved OS and DSS in this study compared to previous reports.
Citation
Shah JP, Levyn H, Valero C, Adilbay D, Eagan A, Zheng J, Gonen M, Cohen M, Patel S, Ganly I, Pai P, Castelnuovo P, Gao FJ, Piazza C, Nicolai P, Panizza B, Bowman J, Barnett C, Kowalski LP, Toledo R, Fliss DM, DeAlmeida J, Witterick I, Herman P, Fontanella W, Aniceto GS, Hosal S, Ozer S, Iyer S, Harvey R, Leemans CR, Hendrickx JJ, Figari M, Boccalatte L, Nibu KI, Clarke P, Rennie C, Ming ZY, Cernea C, Goncalves S, Schlosser R, Dias F, Sargi Z, Ahmed S, Golusinski W, Kim SH, Su SY, Raza SM, DeMonte F, Hanna E. Skull base surgery for malignant tumors: The 2nd international collaborative study (1995-2015). Head Neck. 2024 May 21. doi: 10.1002/hed.27746. Epub ahead of print.
Type
Article