The silent obstruction : a rare complication of non-steroidal anti-inflammatory drug (NSAID) - induced diaphragm disease
Mazhuppel Rechard, Edwin Al-Talib, Ismaeel Saigal, Radhika Sivanandam, Lokesh Koumar
Mazhuppel Rechard, Edwin
Al-Talib, Ismaeel
Saigal, Radhika
Sivanandam, Lokesh Koumar
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Affiliation
The Royal Wolverhampton NHS Trust; Walsall Healthcare NHS Trust; Torbay and South Devon NHS Foundation Trust
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Publication date
2025-11-07
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Abstract
Diaphragm disease is a rare but significant complication of prolonged non-steroidal anti-inflammatory drug (NSAID) use, characterised by thin concentric mucosal diaphragms causing small bowel strictures. This case report is on a 42-year-old woman with a chronic history of NSAID use, which led to the development of recurrent gastrointestinal symptoms, iron-deficiency anaemia, and subacute small bowel obstruction. Diaphragm disease was confirmed through histological analysis following surgical resection of the small bowel. Patients who present with non-specific GI symptoms along with chronic NSAID use and unexplained obstruction should make us consider diaphragm disease within the differentials.
Citation
Mazhuppel Rechard E, Al-Talib I, Saigal R, Sivanandam LK. The Silent Obstruction: A Rare Complication of Non-steroidal Anti-inflammatory Drug (NSAID)-Induced Diaphragm Disease. Cureus. 2025 Nov 7;17(11):e96275. doi: 10.7759/cureus.96275. PMID: 41362542; PMCID: PMC12681954.
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Article