Autoimmune cytopenias developing late post alemtuzumab-based allogeneic stem cell transplantation: presentation of short case series from a transplant center.
Lloyd, Rebecca Nikolousis, Emmanouil Kishore, Bhuvan Lovell, Richard Shankara, Paneesha Zeid, Nervana Abou Panteliadou, Alkistis Kyra McIlroy, Graham Xenou, Evgenia
Lloyd, Rebecca
Nikolousis, Emmanouil
Kishore, Bhuvan
Lovell, Richard
Shankara, Paneesha
Zeid, Nervana Abou
Panteliadou, Alkistis Kyra
McIlroy, Graham
Xenou, Evgenia
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2020-01
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Stem cell transplantation remains the curative option for many patients with hematological malignancies. The long-term effects of these treatments on the patients and their immune systems have been extensively investigated, but there remains a paucity of data regarding autoimmune manifestations post-transplant, although these effects are well recognized.Herein we present the clinical picture and therapeutic approach in three patients (cases 1-3), with varied presentations of autoimmune disease post-transplant. Case 1 exhibited autoimmune hemolytic anemia and other autoimmune manifestations (serositis, thyroiditis), that were probably linked to graft versus relapsed leukemia effect. Cases 2 and 3 had pure red white cell aplasia and pure red cell aplasia, respectively, which were associated with hyperglobulinemia and a clonal T cell expansion.
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Lloyd R, Nikolousis E, Kishore B, Lovell R, Shankara P, Zeid NA, Horgan C, Panteliadou AK, McIlroy G, Xenou E, Kaparou M, Holder K, Murthy V, Kanellopoulos A. Autoimmune Cytopenias Developing Late Post Alemtuzumab-Based Allogeneic Stem Cell Transplantation: Presentation of Short Case Series from a Transplant Center. Cell Transplant. 2020 Jan-Dec;29:963689720950641. doi: 10.1177/0963689720950641
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