Xanthomatous hypophysitis relapsing and remitting over two decades
Nazeer, Kabir Khan Alatrash, Salhin Elsheikh, Sawsan Jacob, Saiju
Nazeer, Kabir Khan
Alatrash, Salhin
Elsheikh, Sawsan
Jacob, Saiju
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Publication date
2025-07-14
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Abstract
Inflammation of the pituitary gland can be primary (without another underlying cause) or secondary (associated with a systemic inflammatory condition). Primary hypophysitis is very rare, among which xanthomatous hypophysitis as a histological type is extremely unusual. A woman in her late 50s presented with recurrent pituitary lesions over 20 years. Her general practitioner had diagnosed panhypopituitarism in her 30s; a decade later, she had presented to ophthalmology with visual loss and restricted visual fields, and a pituitary lesion was found. This recurred several times requiring multiple resections. Histopathology showed atypical inflammation in keeping with xanthomatous hypophysitis; this responded well to corticosteroid therapy. Xanthomatous hypophysitis is a rare form of steroid-responsive primary pituitary inflammation, to consider in the differential diagnosis of recurring pituitary lesions.
Citation
Nazeer KK, Alatrash S, Elsheikh S, Jacob S. Xanthomatous hypophysitis relapsing and remitting over two decades. Pract Neurol. 2025 Jul 14;25(4):359-362
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Journal Article
Case Reports
Case Reports