Approach to Mycosis Fungoides in children: Consensus-based recommendations
Zvulunov, Alex Neale, Holly Stern, Jonah Santaguida, Pasqualina Stein, Amy Buros Koh, Mark Eichenfield, Lawrence F Guitart, Joan Goebeler, Matthias Scarisbrick, Julia
Zvulunov, Alex
Neale, Holly
Stern, Jonah
Santaguida, Pasqualina
Stein, Amy Buros
Koh, Mark
Eichenfield, Lawrence F
Guitart, Joan
Goebeler, Matthias
Scarisbrick, Julia
Citations
Altmetric:
Affiliation
Other Contributors
Publication date
2024-08-23
Collections
Research Projects
Organizational Units
Journal Issue
Abstract
Background: Pediatric Mycosis fungoides (MF) management extrapolates from adult guidelines, despite differing clinical aspects. Recommendations are essential to address unique challenges in this distinct patient group.
Objective: This project aims to derive consensus recommendations for pediatric MF management.
Methods: Experts from pediatric dermatology, general dermatology, dermatopathology, and pediatric hematology-oncology (N = 83) were invited to contribute to consensus recommendations. The process involved 3 electronic Delphi rounds, concluding with a final consensus meeting using a modified Nominal Group Technique for unresolved items.
Results: Consensus included more clinical severity measures than tumor-node-metastasis-blood staging: pruritus, functional or esthetic impairment (eg, palms, soles, genitalia), quality of life impact, and psychological aspects (eg, embarrassment, anxiety, depression), plus parental anxiety. Ten recommendations were made for managing early and advanced pediatric MF. Disagreement emerged in choosing therapies beyond stage I of the disease.
Discussion: This multinational initiative aimed to standardize optimal pediatric MF management and successfully generated consensus recommendations. Additional work is needed for structured, prospective protocols in advanced-stage pediatric MF.
Limitations: Lack of pediatric hematologists-oncologists and patients' representatives.
Conclusion: Documentation of extended clinical severity and outcome measures is recommended. Addressing the need for structured protocols in advanced-stage pediatric MF and implementing systematic, prospective data collection is crucial.
Citation
Zvulunov A, Neale H, Stern J, Santaguida P, Stein AB, Koh M, Eichenfield LF, Guitart J, Goebeler M, Scarisbrick J, Willemze R, Coughlin CC, George R, Brazzelli V, Marschalkó M, Belousova I, Querfeld C, Bagot M, Szepietowski JC, Papadavid E, Quaglino P, Hoeger P, Ortiz-Romero PL, Nikolaou V, Dummer R, Aung PP, Lawley L, Morel KD, Ngan B, Wain M, Gameiro A, Lacy-Niebla RM, Pope E. Approach to Mycosis Fungoides in children: Consensus-based recommendations. J Am Acad Dermatol. 2024 Dec;91(6):1078-1085. doi: 10.1016/j.jaad.2024.07.1501. Epub 2024 Aug 23.
Type
Article
Conference Output
Conference Output