Association between higher morning preference and better health-related quality of life in asthma
Patel, Neel Deprato, Andy Qian, Tina Adan, Ana Akgün, Metin Anderson, Augustus Brickstock, Amanda Eathorne, Allie Garud, Arundhati Haldar, Prasun
Patel, Neel
Deprato, Andy
Qian, Tina
Adan, Ana
Akgün, Metin
Anderson, Augustus
Brickstock, Amanda
Eathorne, Allie
Garud, Arundhati
Haldar, Prasun
Affiliation
University of Alberta; McMaster University; University of Barcelona; Ataturk University; Ağrı İbrahim Çeçen University; Medical Research Institute of New Zealand; University Hospitals Birmingham NHS Foundation Trust; Ahmedabad University; Supreme Institute of Management and Technology Mankundu; Jindal Clinics; Apollo Gleneagles Hospital; University of Birmingham; University of Ferrara
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Publication date
2025-03-19
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Abstract
BACKGROUND: Circadian preference for eveningness has been linked to a higher risk of asthma and allergies, but its association with health-related quality of life (HRQL) in asthma has not been studied yet.
OBJECTIVE: We aimed to investigate the associations between individual circadian preference and HRQL in asthma.
METHODS: Among 691 adult asthma patients from Canada, India, New Zealand, and the United Kingdom, a digital questionnaire was administered to capture demographic information, social and psychologic attributes, comorbidities, and medication adherence. Circadian preference and HRQL were assessed by the reduced version of the morningness-eveningness questionnaire (rMEQ) and the short form of the chronic respiratory questionnaire, respectively. We analyzed the association between chronotype and HRQL using mixed-effect linear regression models.
RESULTS: Of all participants, 59% were female with a mean (standard deviation) age of 49 (17) years. Median (interquartile range) rMEQ total score was 17 (14-19). Mean (standard deviation) dyspnea, fatigue, emotional function, and mastery scores were 5.94 (1.2), 4.38 (1.3), 5.05 (1.3), and 1.96 (1.1), respectively. In regression analysis, a higher rMEQ total score (higher morningness) was associated with less fatigue (β = 0.06; 95% confidence interval, 0.04 to 0.09) and better emotional function (β = 0.03; 95% confidence interval, 0.004 to 0.06), and these associations were mediated by less anxiety, depression, and alcohol abuse, and better sleep quality.
CONCLUSION: Morning orientation is associated with better HRQL in patients with asthma. The results suggest that working with patients to promote schedules and habits related to morningness may be beneficial.
Citation
Patel N, Deprato A, Qian T, Adan A, Akgün M, Anderson A, Brickstock A, Eathorne A, Garud A, Haldar P, Jindal A, Jindal SK, Kerget B, Moitra S, Mukherjee R, Semprini A, Turner AM, Murgia N, Lacy P, Moitra S. Association between higher morning preference and better health-related quality of life in asthma. J Allergy Clin Immunol Glob. 2025 Mar 19;4(2):100456. doi: 10.1016/j.jacig.2025.100456.
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Article