Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study.
Domenighetti, Cloé Sugier, Pierre-Emmanuel Ashok Kumar Sreelatha, Ashwin Schulte, Claudia Grover, Sandeep Mohamed, Océane Portugal, Berta May, Patrick Bobbili, Dheeraj R Radivojkov-Blagojevic, Milena
Domenighetti, Cloé
Sugier, Pierre-Emmanuel
Ashok Kumar Sreelatha, Ashwin
Schulte, Claudia
Grover, Sandeep
Mohamed, Océane
Portugal, Berta
May, Patrick
Bobbili, Dheeraj R
Radivojkov-Blagojevic, Milena
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Affiliation
Université Paris-Saclay; Institute for Clinical Epidemiology and Applied Biometry, University of Tubingen; Hertie Institute for Clinical Brain Research, University of Tubingen; Sandwell and West Birmingham NHS Trust
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Publication date
2022-01-08
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Abstract
Background: Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding.
Objective: The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR).
Methods: We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry).
Results: Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD (odds ratio [OR] per one serving per day = 1.70, 95% confidence interval = 1.12-2.60, P = 0.013) that was restricted to men (OR = 2.50 [1.37-4.56], P = 0.003; P-difference with women = 0.029).
Conclusions: Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms.
Citation
Domenighetti, C., Sugier, P. E., Ashok Kumar Sreelatha, A., Schulte, C., Grover, S., Mohamed, O., Portugal, B., May, P., Bobbili, D. R., Radivojkov-Blagojevic, M., Lichtner, P., Singleton, A. B., Hernandez, D. G., Edsall, C., Mellick, G. D., Zimprich, A., Pirker, W., Rogaeva, E., Lang, A. E., Koks, S., … Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (Courage-PD) Consortium (2022). Dairy Intake and Parkinson's Disease: A Mendelian Randomization Study. Movement disorders : official journal of the Movement Disorder Society, 37(4), 857–864. https://doi.org/10.1002/mds.28902
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Article