Podocyte infolding glomerulopathy masquerading as membranous nephropathy - a shared pathogenesis?
Matthai, Smita Mary Hems, Liam Tsang, Yee Wah Aggarwal, Yogita Mahmoud, Huda Gopalakrishnan, Kishore
Matthai, Smita Mary
Hems, Liam
Tsang, Yee Wah
Aggarwal, Yogita
Mahmoud, Huda
Gopalakrishnan, Kishore
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Affiliation
Christian Medical College; University Hospitals Coventry and Warwickshire NHS Trust; Walsall Healthcare NHS Trust
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Publication date
2024-08-01
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Abstract
Podocyte infolding glomerulopathy (PIG) is a rare pathological entity, diagnosed by electron microscopic demonstration of diffuse infolding of the podocytes into the glomerular basement membranes. We report the first case from United Kingdom exhibiting typical ultrastructural features of PIG in a male with Type II diabetes mellitus, hypertension and common variable immune deficiency. Renal biopsy revealed phospholipase A2 receptor (PLA2R) immunostain positive membranous nephropathy (MN) but no serum PLA2R antibodies. Diffuse infolding of the podocytes into the glomerular basement membranes along with pathognomonic microspherular and microtubular intra basement membrane clusters distributed diffusely and globally were noted on electron microscopy, diagnostic of PIG. We postulate a shared pathomechanistic link between PIG and MN, highlighting the overlapping features of both conditions.
Citation
Matthai SM, Hems L, Tsang YW, Aggarwal Y, Mahmoud H, Gopalakrishnan K. Podocyte Infolding Glomerulopathy Masquerading as Membranous Nephropathy - A Shared Pathogenesis? Indian J Nephrol. 2024 Jul-Aug;34(4):397-400. doi: 10.25259/ijn_209_23. Epub 2024 Jun 24. PMID: 39156853; PMCID: PMC11326786.
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