Malignant phyllodes tumor of the breast: a systematic review.
Lissidini, Germana Mulè, Antonino Santoro, Angela Papa, Giovanni Nicosia, Luca Cassano, Enrico Ashoor, Arwa Ahmed Veronesi, Paolo Pantanowitz, Liron Hornick, Jason L
Lissidini, Germana
Mulè, Antonino
Santoro, Angela
Papa, Giovanni
Nicosia, Luca
Cassano, Enrico
Ashoor, Arwa Ahmed
Veronesi, Paolo
Pantanowitz, Liron
Hornick, Jason L
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Affiliation
European Institute of Oncology; Catholic University Rome; University of Trieste; Sandwell and West Birmingham NHS Trust; et al
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Publication date
2022-04-13
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Abstract
Phyllodes tumors (PT) are fibroepithelial neoplasms of the breast showing a peculiar leaf-like appearance. They account for 0.3 to 1% of all primary breast tumors and 2.5% of all fibroepithelial breast tumors. PT are classified into benign, borderline and malignant based upon their stromal morphology with a distribution of 60%, 20%, and 20%, respectively. Malignant PT of the breast constitute an uncommon challenging group of fibroepithelial neoplasms. They have a relatively high tendency to recur, although distant metastasis is uncommon, and nearly exclusive to malignant PT. Adequate surgical resection remains the standard approach to achieve maximal local control. Giant malignant PT are rare and a pose a diagnostic dilemma for pathologists, especially when comprised of sarcomatous elements. This review highlights the morphological features of PT detected in cytology and histology specimens and discusses diagnostic pitfalls and differential diagnosis.
Citation
Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED. Malignant phyllodes tumor of the breast: a systematic review. Pathologica. 2022 Apr;114(2):111-120. doi: 10.32074/1591-951X-754
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Article