Addressing comorbidities in people with Parkinson's Disease : considerations from an expert panel
Carroll, Camille Grosset, Donald Rather, Arshad Mohamed, Biju Parry, Miriam Reddy, Prashanth Fackrell, Robin Chaudhuri, Kallol Ray
Carroll, Camille
Grosset, Donald
Rather, Arshad
Mohamed, Biju
Parry, Miriam
Reddy, Prashanth
Fackrell, Robin
Chaudhuri, Kallol Ray
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Affiliation
Newcastle University; University Hospitals Plymouth NHS Trust; Sandwell and West Birmingham NHS Trust; University of Glasgow; et al.
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Publication date
2024-01
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Abstract
In the UK, guidance exists to aid clinicians and patients deciding when treatment for Parkinson's disease (PD) should be initiated and which therapies to consider. National Institute for Health and Care Excellence (NICE) guidance recommends that before starting PD treatment clinicians should discuss the following: the patient's individual clinical circumstances; lifestyle; preferences; needs and goals; as well as the potential benefits and harms of the different drug classes. Individualization of medicines and management in PD significantly improves patients' outcomes and quality of life. This article aims to provide simple and practical guidance to help clinicians address common, but often overlooked, co-morbidities. A multi-disciplinary group of PD experts discussed areas where clinical care can be improved by addressing commonly found co-morbidities in people with Parkinson's (PwP) based on clinical experience and existing literature, in a roundtable meeting organized and funded by Bial Pharma UK Ltd. The experts identified four core areas (bone health, cardiovascular risk, anticholinergic burden, and sleep quality) that, if further standardized may improve treatment outcomes for PwP patients. Focusing on anticholinergic burden, cardiac risk, sleep, and bone health could offer a significant contribution to personalizing regimes for PwP and improving overall patient outcomes. Within this opinion-based paper, the experts offer a list of guiding factors to help practitioners in the management of PwP.
Citation
Carroll C, Clarke CE, Grosset D, Rather A, Mohamed B, Parry M, Reddy P, Fackrell R, Chaudhuri KR. Addressing Comorbidities in People with Parkinson's Disease: Considerations From An Expert Panel. J Parkinsons Dis. 2024;14(1):53-63. doi: 10.3233/JPD-23016
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Article