The roles of DGAT1 and DGAT2 in human myotubes are dependent on donor patho-physiological background
Gharanei, Seley
Gharanei, Seley
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Irshad Z; Lund J; Sillars A; Løvsletten NG; Gharanei S; Salt IP; Freeman DJ; Gill JMR; Thoresen GH; Rustan AC; Zammit VA
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2023-11
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Abstract
The roles of DGAT1 and DGAT2 in lipid metabolism and insulin responsiveness of human skeletal muscle were studied using cryosections and myotubes prepared from muscle biopsies from control, athlete, and impaired glucose regulation (IGR) cohorts of men. The previously observed increases in intramuscular triacylglycerol (IMTG) in athletes and IGR were shown to be related to an increase in lipid droplet (LD) area in type I fibers in athletes but, conversely, in type II fibers in IGR subjects.
Citation
Zehra Irshad 1, Jenny Lund 2, Anne Sillars 3, Nils Gunnar Løvsletten 2, Seley Gharanei 1 4, Ian P Salt 5, Dilys J Freeman 3, Jason M R Gill 3, G Hege Thoresen 2 6, Arild C Rustan 2, Victor A Zammit 1
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Article