Recommendations to promote equity, diversity and inclusion in decentralized clinical trials
Aiyegbusi, Olalekan Lee Cruz Rivera, Samantha Kamudoni, Paul Anderson, Nicola Collis, Philip Denniston, Alastair K Harding, Rosie Hughes, Sarah E Khunti, Kamlesh Kotecha, Dipak
Aiyegbusi, Olalekan Lee
Cruz Rivera, Samantha
Kamudoni, Paul
Anderson, Nicola
Collis, Philip
Denniston, Alastair K
Harding, Rosie
Hughes, Sarah E
Khunti, Kamlesh
Kotecha, Dipak
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2024-10-29
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Abstract
Decentralized clinical trials involving the use of digital tools to facilitate remote research are gaining momentum. Rapid advancements in digital technologies have supported the adoption of these trials. These innovations facilitate virtual interactions between clinical trial teams and participants by making it easier to collect, transfer and store electronic data. While some studies have demonstrated the potential for these approaches to reduce barriers to clinical trial participation, they are associated with several challenges that may create or worsen existing health inequalities and limit the generalizability of trial results. Here we review the potential for digitally enabled and decentralized clinical trials to enhance clinical trial participation in an equitable manner. We describe the key barriers individuals from underserved groups may face, and provide recommendations to promote equity, diversity and inclusion.
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Aiyegbusi OL, Cruz Rivera S, Kamudoni P, Anderson N, Collis P, Denniston AK, Harding R, Hughes SE, Khunti K, Kotecha D, Krumholz H, Liu X, McMullan C, Molony-Oates B, Monteiro J, Myles P, Rantell KR, Soltys K, Verdi R, Wilson R, Calvert MJ. Recommendations to promote equity, diversity and inclusion in decentralized clinical trials. Nat Med. 2024 Nov;30(11):3075-3084. doi: 10.1038/s41591-024-03323-w. Epub 2024 Oct 29.
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