Predictors of the efficacy of his bundle pacing in patients with a prolonged PR interval: A stratified analysis of the HOPE-HF randomized controlled trial.
Keene, Daniel Kaza, Nandita Srinivasan, Divya Ali, Nadine Tanner, Mark Foley, Paul Chandrasekaran, Badri Moore, Philip Adhya, Shaumik Qureshi, Norman
Keene, Daniel
Kaza, Nandita
Srinivasan, Divya
Ali, Nadine
Tanner, Mark
Foley, Paul
Chandrasekaran, Badri
Moore, Philip
Adhya, Shaumik
Qureshi, Norman
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2024-07-18
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Abstract
The randomized, double-blind, placebo-controlled HOPE-HF trial assessed the benefit of atrio-ventricular (AV) delay optimization delivered using His bundle pacing. It recruited patients with left ventricular ejection fraction ≤40%, PR interval ≥200 ms, and baseline QRS ≤140 ms or right bundle branch block. Overall, there was no significant increase in peak oxygen uptake (VO2max) but there was significant improvement in heart failure specific quality of life. In this pre-specified secondary analysis, we evaluated the impact of baseline PR interval, echocardiographic E-A fusion, and the magnitude of acute high-precision haemodynamic response to pacing, on outcomes.
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Keene D, Kaza N, Srinivasan D, Ali N, Tanner M, Foley P, Chandrasekaran B, Moore P, Adhya S, Qureshi N, Muthumala A, Lane R, Rinaldi A, Agarwal S, Leyva F, Behar J, Bassi S, Ng A, Scott P, Prasad R, Swinburn J, Tomson J, Sethi A, Shah J, Lim PB, Kyriacou A, Thomas D, Chuen J, Kamdar R, Kanagaratnam P, Mariveles M, Johnson N, Falaschetti E, Howard JP, Arnold A, Cleland JGF, Francis DP, Whinnett Z, Shun-Shin M. Predictors of the efficacy of His bundle pacing in patients with a prolonged PR interval: A stratified analysis of the HOPE-HF randomized controlled trial. Eur J Heart Fail. 2024 Jul 18. doi: 10.1002/ejhf.3367. Epub ahead of print.
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