Obesity-related glomerulopathy : a lesser known complication of obesity
Sharma, Sourabh Sharma, Alok Kapoor, Nitin Sharma, Neha Saravanan, Ponnusamy Kalra, Sanjay
Sharma, Sourabh
Sharma, Alok
Kapoor, Nitin
Sharma, Neha
Saravanan, Ponnusamy
Kalra, Sanjay
Affiliation
Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India; Lal Path Labs, New Delhi, India; Christian Medical College, Vellore, India; Baker Heart and Diabetes Institute, Melbourne, Australia; University of Warwick, Coventry; George Eliot Hospital NHS Trust, Nuneaton; Bharti Hospital, Karnal, India; Chandigarh University, Mohali, India
Other Contributors
Publication date
2025-09-08
Subject
Collections
Research Projects
Organizational Units
Journal Issue
Abstract
Purpose of review: Obesity is a global health concern and is intricately linked to cardiovascular disease and metabolic disorders. While its causal association with chronic kidney disease (CKD) has also been recognized, this entity has not been discussed extensively. Obesity-related glomerulopathy (ORG) is pathologically a secondary form of focal segmental glomerulosclerosis (FSGS), which typically presents clinically with subnephrotic proteinuria, and histopathologically as glomerulomegaly, and the perihilar variant of FSGS.
Recent findings: This review discusses the latest update on pathophysiology, risk factors, clinical features, diagnosis, prevention, staging, and management of ORG. Special emphasis is placed on diagnostic criteria distinguishing ORG from other FSGS variants and CKD aetiologies.
Summary: While obesity can impact renal health, renal status influences choice of antiobesity medication as well. Early recognition and intervention are critical to preventing progression to end-stage kidney disease.
Citation
Sharma S, Sharma A, Kapoor N, Sharma N, Saravanan P, Kalra S. Obesity-related glomerulopathy: a lesser known complication of obesity. Curr Opin Endocrinol Diabetes Obes. 2025 Sep 8. doi: 10.1097/MED.0000000000000930. Epub ahead of print.
Type
Article