Exosomes as perioperative therapeutics to limit organ injury.
Owen, Andrew Stary, Creed M Gross, Eric R
Owen, Andrew
Stary, Creed M
Gross, Eric R
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2023-01-20
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Abstract
Perioperative organ injury is a frequent and major complication for the ∼240 million people undergoing surgery worldwide annually. Ischaemic preconditioning is a powerful technique that reduces organ injury in experimental models of heart, lung, gut, brain, and kidney ischaemia-reperfusion injury. However, ischaemic preconditioning has been a challenge to translate into clinical practice. We describe how utilising isolated pre-conditioned exosomes (secreted vesicles containing many cell-survival mediators), some of the translational hurdles of ischaemic preconditioning can be overcome. Delivery of exosomes in the perioperative period could become a promising new therapeutic strategy to prevent perioperative organ injury.
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Owen A, Stary CM, Gross ER. Exosomes as perioperative therapeutics to limit organ injury. Br J Anaesth. 2023 Mar;130(3):248-250. doi: 10.1016/j.bja.2022.12.014. Epub 2023 Jan 20
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