HIV-negative Kaposi sarcoma manifesting as foot lesion in a patient with diabetes mellitus: a case study.
Khan, Farishta Millette, Dijon Siddique, Roshan Siddique, Haroon
Khan, Farishta
Millette, Dijon
Siddique, Roshan
Siddique, Haroon
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Affiliation
Norfolk and Norwich University Hospitals NHS Foundation Trust; Mersey and West Lancashire Teaching Hospitals NHS Trust; St George's University of London; The Dudley Group NHS Foundation Trust
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Publication date
2024-02-22
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Abstract
Kaposi's sarcoma caused by Kaposi's sarcoma-associated virus, is a rare malignancy in the general population with unique features. However, clinical presentation on the feet can mimic a diabetic foot ulcer. Here we describe the case of a 63-year-old male with type 2 diabetes, who presented with a lesion on the left 4th toe. Left foot radiograph in lateral and dorsoplantar views were normal. Full skin examination identified lesions with a similar morphology on the forearms. A HIV antigen/antibody test was negative, histology showed CD31 positive spindle cells and the presence of Kaposi's sarcoma-associated virus confirming the diagnosis of Kaposi's sarcoma. Kaposi's sarcoma-associated virus' lytic cycle can be triggered by the immunosuppressive state caused by tissue's chronic exposure to a hyperglycaemic environment. A thorough general examination to identify lesions elsewhere in the body can help to identify the systemic nature of the disease. Pedal lesions in patients with diabetes with an atypical presentation that are refractory to standard treatment should prompt early histological examination. Early diagnosis and intervention can improve the chances of remission.
Citation
Khan F, Millette D, Siddique R, Siddique H. HIV-negative Kaposi sarcoma manifesting as foot lesion in a patient with diabetes mellitus: a case study.�Wounds UK. 2024;20(1):9-11. Accessed July 24, 2024