Outcomes of Heavy Silicone Oil (Densiron) compared to Silicone Oil in primary rhegmatogenous retinal detachment: a multivariable regression model.
Author
Moussa, GeorgeTadros, Maria
Ch'ng, Soon Wai
Sharma, Ash
Lett, Kim Son
Mitra, Arijit
Tyagi, Ajai K
Andreatta, Walter
Affiliation
University of Birmingham; Sandwell and West, Birmingham NHS Trust; Kantonsspital Winterthur; University of ZurichPublication date
2022-09-03Subject
Ophthalmology
Metadata
Show full item recordAbstract
Purpose: To measure the visual outcomes, proliferative vitreoretinopathy (PVR) and retinectomy rates following primary rhegmatogenous retinal detachment (RRD) repair, comparing silicone oil (SO) and heavy SO (Densiron). Methods: Retrospective, continuous comparative study from January 2017 to May 2021 of all primary RRD. Multivariable linear (logMAR gain) and binary-logistic (PVR-C and retinectomy rate) regression models to compare tamponade were performed. Covariates included age, gender, ocular co-morbidities, high myopia, macula-status, giant-retinal-tear (GRT), pre-op vision, PVR-C, oil type, perfluorocarbon-use, combined scleral buckle/vitrectomy, combined phaco-vitrectomy, 360-degrees-endolaser and oil duration. Cases with trauma or less than six-month follow-up were excluded. Results: A total of 259 primary RD were analysed. There were 179 SO patients and 80 Densiron patients that had six-month primary re-detachment in 18 (10.1%) and 8 (10.0%) respectively (p = 1.000). No difference in logMAR gain was detected between tamponade choice on multivariable linear regression. Subsequent glaucoma surgery was 5 (2.8%) and 4 (5.0%) for SO and Densiron patients respectively (p = 0.464). On multivariate binary-logistic regression we found no difference in development of PVR-C between oil tamponades. However, SO had significantly higher subsequent retinectomy rate compared to Densiron (odds ratio 15.3, 95% CI 1.9-125.5, p = 0.011). Duration of oil tamponade was not linked to differences in logMAR gain, PVR-C formation or increased retinectomy rate. Conclusions: We report no difference in primary anatomical success, number of further RRD surgeries, subsequent glaucoma surgery, visual outcomes, PVR-C between both tamponades on multivariable models. Densiron oil was found to be more retinectomy sparing relative to SO.Citation
Moussa G, Tadros M, Ch'ng SW, Sharma A, Lett KS, Mitra A, Tyagi AK, Andreatta W. Outcomes of Heavy Silicone Oil (Densiron) compared to Silicone Oil in primary rhegmatogenous retinal detachment: a multivariable regression model. Int J Retina Vitreous. 2022 Sep 3;8(1):61. doi: 10.1186/s40942-022-00413-0Type
ArticlePMID
36057670Publisher
BMCae974a485f413a2113503eed53cd6c53
10.1186/s40942-022-00413-0