ADAMS project: a genetic association study in individuals from diverse ancestral backgrounds with multiple sclerosis based in the UK.
Author
Jacobs, Benjamin MSchalk, Luisa
Dunne, Angie
Scalfari, Antonio
Nandoskar, Ashwini
Gran, Bruno
Mein, Charles A
Sellers, Charlotte
Spilker, Cord
Rog, David
Visentin, Elisa
Bezzina, Elizabeth Lindsey
Uzochukwu, Emeka
Tallantyre, Emma
Wozniak, Eva
Sacre, Eve
Hassan-Smith, Ghaniah
Ford, Helen L
Harris, Jade
Bradley, Joan
Breedon, Joshua
Brooke, Judith
Kreft, Karim L
Tuite Dalton, Katherine
George, Katila
Papachatzaki, Maria
O'Malley, Martin
Peter, Michelle
Mattoscio, Miriam
Rhule, Neisha
Evangelou, Nikos
Vinod, Nimisha
Quinn, Outi
Shamji, Ramya
Kaimal, Rashmi
Boulton, Rebecca
Tanveer, Riffat
Middleton, Rod
Murray, Roxanne
Bellfield, Ruth
Hoque, Sadid
Patel, Shakeelah
Raj, Sonia
Gumus, Stephanie
Mitchell, Stephanie
Sawcer, Stephen
Arun, Tarunya
Pogreban, Tatiana
Brown, Terri-Louise
Begum, Thamanna
Antoine, Veronica
Rashid, Waqar
Noyce, Alastair J
Silber, Eli
Morris, Huw
Giovannoni, Gavin
Dobson, Ruth
Publication date
2023-05-17Subject
Neurology
Metadata
Show full item recordAbstract
Purpose: Genetic studies of multiple sclerosis (MS) susceptibility and severity have focused on populations of European ancestry. Studying MS genetics in other ancestral groups is necessary to determine the generalisability of these findings. The genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis (ADAMS) project aims to gather genetic and phenotypic data on a large cohort of ancestrally-diverse individuals with MS living in the UK. Participants: Adults with self-reported MS from diverse ancestral backgrounds. Recruitment is via clinical sites, online (https://app.mantal.co.uk/adams) or the UK MS Register. We are collecting demographic and phenotypic data using a baseline questionnaire and subsequent healthcare record linkage. We are collecting DNA from participants using saliva kits (Oragene-600) and genotyping using the Illumina Global Screening Array V.3. Findings to date: As of 3 January 2023, we have recruited 682 participants (n=446 online, n=55 via sites, n=181 via the UK MS Register). Of this initial cohort, 71.2% of participants are female, with a median age of 44.9 years at recruitment. Over 60% of the cohort are non-white British, with 23.5% identifying as Asian or Asian British, 16.2% as Black, African, Caribbean or Black British and 20.9% identifying as having mixed or other backgrounds. The median age at first symptom is 28 years, and median age at diagnosis is 32 years. 76.8% have relapsing-remitting MS, and 13.5% have secondary progressive MS. Future plans: Recruitment will continue over the next 10 years. Genotyping and genetic data quality control are ongoing. Within the next 3 years, we aim to perform initial genetic analyses of susceptibility and severity with a view to replicating the findings from European-ancestry studies. In the long term, genetic data will be combined with other datasets to further cross-ancestry genetic discoveries.Citation
Jacobs BM, Schalk L, Dunne A, Scalfari A, Nandoskar A, Gran B, Mein CA, Sellers C, Spilker C, Rog D, Visentin E, Bezzina EL, Uzochukwu E, Tallantyre E, Wozniak E, Sacre E, Hassan-Smith G, Ford HL, Harris J, Bradley J, Breedon J, Brooke J, Kreft KL, Tuite Dalton K, George K, Papachatzaki M, O'Malley M, Peter M, Mattoscio M, Rhule N, Evangelou N, Vinod N, Quinn O, Shamji R, Kaimal R, Boulton R, Tanveer R, Middleton R, Murray R, Bellfield R, Hoque S, Patel S, Raj S, Gumus S, Mitchell S, Sawcer S, Arun T, Pogreban T, Brown TL, Begum T, Antoine V, Rashid W, Noyce AJ, Silber E, Morris H, Giovannoni G, Dobson R. ADAMS project: a genetic Association study in individuals from Diverse Ancestral backgrounds with Multiple Sclerosis based in the UK. BMJ Open. 2023 May 17;13(5):e071656. doi: 10.1136/bmjopen-2023-071656.Type
ArticlePMID
37197821Journal
BMJ OpenPublisher
BMJ Publishing Groupae974a485f413a2113503eed53cd6c53
10.1136/bmjopen-2023-071656