Recent Submissions

  • Pregnancies in women with Turner syndrome: a retrospective multicentre UK study

    Cauldwell, M; Steer, P J; Adamson, D; Alexander, C; Allen, L; Bhagra, C; Bolger, A; Bonner, S; Calanchini, M; Carroll, A; et al. (Wiley-Blackwell, 2022-03-22)
    Objective: To determine the characteristics and outcomes of pregnancy in women with Turner syndrome. Design: Retrospective 20-year cohort study (2000-20). Setting: Sixteen tertiary referral maternity units in the UK. Population or sample: A total of 81 women with Turner syndrome who became pregnant. Methods: Retrospective chart analysis. Main outcome measures: Mode of conception, pregnancy outcomes. Results: We obtained data on 127 pregnancies in 81 women with a Turner phenotype. All non-spontaneous pregnancies (54/127; 42.5%) were by egg donation. Only 9/31 (29%) pregnancies in women with karyotype 45,X were spontaneous, compared with 53/66 (80.3%) pregnancies in women with mosaic karyotype 45,X/46,XX (P < 0.0001). Women with mosaic karyotype 45,X/46,XX were younger at first pregnancy by 5.5-8.5 years compared with other Turner syndrome karyotype groups (P < 0.001), and more likely to have a spontaneous menarche (75.8% versus 50% or less, P = 0.008). There were 17 miscarriages, three terminations of pregnancy, two stillbirths and 105 live births. Two women had aortic dissection (2.5%); both were 45,X karyotype with bicuspid aortic valves and ovum donation pregnancies, one died. Another woman had an aortic root replacement within 6 months of delivery. Ten of 106 (9.4%) births with gestational age data were preterm and 22/96 (22.9%) singleton infants with birthweight/gestational age data weighed less than the tenth centile. The caesarean section rate was 72/107 (67.3%). In only 73/127 (57.4%) pregnancies was there documentation of cardiovascular imaging within the 24 months before conceiving. Conclusions: Pregnancy in women with Turner syndrome is associated with major maternal cardiovascular risks; these women deserve thorough cardiovascular assessment and counselling before assisted or spontaneous pregnancy managed by a specialist team.
  • Streptococcus pyogenes brain abscess: a tertiary hospital experience

    Sabtu, Nurfarah; Medical and Dental; A Pattinson, P Harjot, TR Augustin, S Ambapkar, R Dardis, and N Sabtu (Univerisity Hospitals, Coventry and Warwickshire NHS Trust, 2024)
    No Abstract
  • Evaluation of hydroxychloroquine or chloroquine for the prevention of COVID-19 (COPCOV): A double-blind, randomised, placebo-controlled trial.

    Schilling, William H K; Mukaka, Mavuto; Callery, James J; Llewelyn, Martin J; Cruz, Cintia V; Dhorda, Mehul; Ngernseng, Thatsanun; Waithira, Naomi; Ekkapongpisit, Maneerat; Watson, James A; et al. (PLOS Medicine, 2024-09-12)
    No Abstract
  • Trauma in the elderly: a bilateral rectus sheath haematoma.

    McArdle, Michael; McArdle, Michael; Emergency Medicine; Care of the Elderly; Medical and Dental; University Hospitals Coventry and Warwickshire NHS Trust (BMJ, 2023-12-07)
    Life expectancy has more than doubled in the last century, and a new cohort of elderly and increasingly frail patients is presenting to emergency departments with new clinical challenges. When this patient cohort presents after injury, all aspects of clinical practice have to be recalibrated to provide safe and appropriate care. The prevalence of chronic disease, levels of organ failure, multiple comorbidities, greater use of anticoagulation and incidence of recurrent low- and high-impact trauma may delay and obscure diagnosis and, ultimately, increase mortality.Older age is a risk factor for rectus sheath haematoma (RSH), which is haemorrhage into the potential space surrounding the rectus abdominis muscle/s. It is a rare presentation following trauma but can provide diagnostic challenges and be fatal. Even more rare is bilateral RSH with only 12 reported in the literature since 1981.This case report describes bilateral RSH presenting in an elderly woman following a fall and the consequences of seemingly minor trauma in the elderly.
  • Patterns, timing and predictors of recurrence following pancreaticoduodenectomy for distal cholangiocarcinoma: An international multicentre retrospective cohort study.

    Labib, Peter Lz; Russell, Thomas B; Denson, Jemimah L; Puckett, Mark A; Ausania, Fabio; Pando, Elizabeth; Roberts, Keith J; Kausar, Ambareen; Mavroeidis, Vasileios K; Bhogal, Ricky H; et al. (Elsevier, 2024-04-22)
    Introduction: Patients undergoing pancreaticoduodenectomy for distal cholangiocarcinoma (dCCA) often develop cancer recurrence. Establishing timing, patterns and risk factors for recurrence may help inform surveillance protocol strategies or select patients who could benefit from additional systemic or locoregional therapies. This multicentre retrospective cohort study aimed to determine timing, patterns, and predictive factors of recurrence following pancreaticoduodenectomy for dCCA. Materials and methods: Patients who underwent pancreaticoduodenectomy for dCCA between June 2012 and May 2015 with five years of follow-up were included. The primary outcome was recurrence pattern (none, local-only, distant-only or mixed local/distant). Data were collected on comorbidities, investigations, operation details, complications, histology, adjuvant and palliative therapies, recurrence-free and overall survival. Univariable tests and regression analyses investigated factors associated with recurrence. Results: In the cohort of 198 patients, 129 (65%) developed recurrence: 30 (15%) developed local-only recurrence, 44 (22%) developed distant-only recurrence and 55 (28%) developed mixed pattern recurrence. The most common recurrence sites were local (49%), liver (24%) and lung (11%). 94% of patients who developed recurrence did so within three years of surgery. Predictors of recurrence on univariable analysis were cancer stage, R1 resection, lymph node metastases, perineural invasion, microvascular invasion and lymphatic invasion. Predictors of recurrence on multivariable analysis were female sex, venous resection, advancing histological stage and lymphatic invasion. Conclusion: Two thirds of patients have cancer recurrence following pancreaticoduodenectomy for dCCA, and most recur within three years of surgery. The commonest sites of recurrence are the pancreatic bed, liver and lung. Multiple histological features are associated with recurrence.
  • FOUND Trial: randomised controlled trial study protocol for case finding of obstructive sleep apnoea in primary care using a novel device

    Miller, Michelle A; Yu, Ly-Mee; Ali, Asad; Apenteng, Patricia; Auguste, Peter; Dale, Jeremy; Hope, Kath; Shanyinde, Milensu; Grabey, Jenna; Scott, Emma; et al. (BMJ Open, 2024-07-25)
    Randomised controlled trial of case finding of OSA in general practice using a novel Medicines and Healthcare products Regulatory Agency-registered device (AcuPebble SA100) compared with usual care with internal feasibility phase. A diverse sample of general practices (approximately 40) from across the West Midlands Clinical Research Network will identify participants from their records. Eligible participants will be aged 50-70 years with body mass index >30 kg/m2 and diabetes (type 1 or 2) and/or hypertension (office blood pressure >145/90 mm Hg or on treatment). They will exclude individuals with known OSA or chronic obstructive pulmonary disease, or those they deem unable to take part. After eligibility screening, consent and baseline assessment, participants will be randomised to either the intervention or control group. Participants in the intervention arm will receive by post the AcuPebble sleep test kit. Those in the control arm will continue with usual care. Follow-up questionnaires will be completed at 6 months. The study is powered (90%) to detect a 5% difference and will require 606 patients in each arm (713 will be recruited to each arm to allow for attrition). Due to the nature of the intervention, participants and GPs will not be blinded to the allocation.
  • Sex-Differences in Alpha-1 Antitrypsin Deficiency: Data From the EARCO Registry

    Miravitlles, Marc; Turner, Alice M; Torres-Duran, María; Tanash, Hanan; Rodríguez-García, Carlota; López-Campos, José Luis; Chlumsky, Jan; Guimaraes, Catarina; Rodríguez-Hermosa, Juan Luis; Corsico, Angelo; et al. (International Journal of Spanish Respiratory Society of Pulmonology and Thoracic Surgery, 2022-12-16)
    Sex and gender influence many aspects of chronic obstructive pulmonary disease (COPD). Limited data are available on this topic in alpha-1 antitrypsin deficiency (AATD). We therefore aimed to investigate sex issues in the EARCO registry, a prospective, international, observational cohort study.
  • Looking for new biomarkers in bronchiectasis (BE): sputum alpha-1 antitrypsin, neutrophil elastase activity and secretory leucocyte protease inhibitor and their role in bronchiectasis airways

    Lara, Beatriz; Medical and Dental; Traversi L, Pons C, Gallego M, Lara B, Suarez G, Tagliabue A, Ahroud M, Felipe Am Clofent D, Loor K, Alvarez A, Culebras M, Polverino E (Poster Presentation, 2024)
    No Abstract
  • Impact of colonoscopy on health-related quality of life: findings from the RECEDE study.

    Andronis, L; Waugh, N; Zanganeh, M; Krishnamoorthy, A; Parsons, N; Hull, M; Wheatstone, P; Arasaradnam, R P; Arasaradnam, Ramesh; Medical and Dental; et al. (Health Qual Life Outcomes, 2024-06-26)
    Background: Colonoscopy is a valuable diagnostic tool but the procedure and the preparation for it cause anxiety and discomfort that impacts on patients' health-related quality of life (HRQoL). The 'disutility' of undergoing an invasive colonoscopy needs to be considered and accounted for in comprehensive cost-utility analyses that compare different diagnostic strategies, yet there is little empirical evidence that can be used in such studies. To fill this gap, we collected and analysed data on the effect of a colonoscopy examination on patients' HRQoL that can be used in economic evaluations.
  • Central Commissioned Training Program November 2023 Palliative Care for Patients with End Stage Renal Diseases (Evening Symposium)

    Murphy, Emma; Nursing and Midwifery Registered; Dr Emma Murphy (Organized by Central Committee (Palliative Care)., 2023)
    No Abstract
  • Central Commissioned Training Program November 2023 Palliative Care for Patients with End Stage Renal Diseases

    Murphy, Emma; Nursing and Midwifery Registered; Dr Emma Murphy (Organized by Central Committee (Palliative Care), 2023)
    No Abstract
  • Central Commissioned Training Program November 2023 Palliative Care for Patients with End Stage Renal Diseases (Afternoon Symposium) Organized by Central Committee (Palliative Care). Keynote: Clinical research in renal palliative care

    Murphy, Emma; Nursing and Midwifery Registered; Dr Emma Murphy (Clinical research in renal palliative care talk by Dr Emma Murphy (UK) & Dr Frank Brennan (Australia, 2023)
    No Abstract
  • NIHR Filming Online Education Programme - Post-doctoral clinical academic careers.

    Murphy, Emma; Nursing and Midwifery Registered; Murphy Emma (NIHR Filming Online Education Programme, 2023)
    No Abstract
  • NIHR Postdoctoral Nursing, Midwifery, and Allied Health Professionals Colloquium

    Murphy, Emma; Nursing and Midwifery Registered; NIHR Postdoctoral Nursing, Midwifery, and Allied Health Professionals Colloquium – hosted by NIHR Nursing and Midwifery in collaboration with the NIHR Nursing and Midwifery Incubator. Regent’s Park London October 2023. Clinical Academics – Opening address: Dr Emma Murphy. (Regent’s Park London October 2023. Clinical Academics, 2024)
    No Abstract
  • Palliative Care in Kidney Disease Murphy Palliative Care in Specific Disease Groups

    Murphy, Emma; Nursing and Midwifery Registered; E Murtagh FEM, . D. MacLeod, L. Van den Block (eds.) (Textbook of Palliative Care, 2024)
    No Abstract
  • Symptom Management in Organ Failure (renal failure) in Challenging Cases in Palliative Care

    Murphy, Emma; Nursing and Midwifery Registered; Steph Flynn and Emma Murphy. Symptom Management in Organ Failure (renal failure) in Challenging Cases in Palliative Care. Oxford University Press. May 2024. (Oxford University Press, 2024-05)
    No Abstract
  • Development of a Resource for Health Professionals to Raise Advance Care Planning Topics During Kidney Care Consultations: A Multiple User-Centred Design.

    Murphy, Emma; Nursing and Midwifery Registered; Anna E Winterbottom; Helen Hurst; Fliss EM Murtagh; Hilary L Bekker; Paula Ormandy; Barnaby Hole; Emma Murphy; Lynne Russon; Andrew Mooney; Keith Bucknall (Kidney Medicine, 2024)
    No Abstract
  • Preparing for responsive management versus preparing for renal dialysis in multimorbid older people with advanced chronic kidney disease (Prepare for Kidney Care): study protocol for a randomised controlled trial.

    Murphy, Emma; Nursing and Midwifery Registered; Jo Worthington; Alexandra Soundy; Jessica Frost; Leila Rooshenas; Stephanie MacNeill; Alba Realpe Rojas; Kirsty Garfield; Yumeng Liu; Karen Alloway; Yoav Ben-Shlomo; Aine Burns; Joseph Chilcot; Jos Darling; Simon Davis; Ken Farrington; Andrew Gibson; Samantha Husbands; Richard Huxtable; Helen McNally; Emma Murphy; Fliss E M Murtagh; Hugh Rayner; Caoimhe Rice; Paul Roderick; Chris Sailsbury; Jodi Taylor; Helen Winton; Jenny Donovan; Joanna Coast; J Athene Lane; Fergus J Caskey (Trials, 2024)
    No Abstract
  • Understanding and addressing symptoms for those with kidney failure managed conservatively, without dialysis: considerations and models of care.

    Murphy, Emma; Murtagh, Fliss E M; Murphy, Emma; Nursing and Midwifery Registered; Murphy E, Murtagh FEM (Annals of Palliative Medicine, 2024-06-18)
    No Abstract
  • A good practice guide on all aspects of ionising radiation protection in the clinical environment: IPEM Report 112

    Rowley, Lisa; Additional Professional Scientific and Technical Field; John Saunderson (Ed.), Mohamed Metwaly (Ed.), William Mairs, Philip Mayles, Lisa Rowley, Mark Worrall (IPEM–IOP Series in Physics and Engineering in Medicine and Biology., 2024-06)
    Full abstract • Retention of current advice where it is still best practice. • Updated advice to cover new radiation regulations. • Updated advice on new imaging modalities and hybrid imaging. • Updated advice on therapeutic nuclear medicine, covering the new radiopharmaceuticals now in use. • Close liaison with the UK regulators in the revision. Copyright © IOP Publishing Ltd 2024 Online ISBN: 978-0-7503-2332-1 • Print ISBN: 978-0-7503-2330-7

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