Recent Submissions

  • Changes in body composition and average daily energy expenditure of men and women during arduous extended polar travel.

    Wilson, Adrian J; Gifford, Robert M; Crosby, Henry; Davey, Sarah; Taylor, Natalie; Eager, Mike; Thake, C Doug; Imray, Christopher H E; Medical and Dental (Plos One, 2024-10-10)
    Weight and skin-fold measurements were made at five-day intervals during a 47-day expedition by six men and three women from the edge of the sea ice to the South Pole. From these, together with detailed manual records of the nutrition for individual participants, the average daily energy expenditure was determined before and after a resupply at approximately mid-point of the expedition. For all participants body weight fell during the expedition with the overall loss being much smaller for the three female participants (-4.0, -4.0, -4.4kg) than for the male participants, (mean±sd) -8.6±2.0kg. Fat weight fell approximately linearly during the expedition with a total loss of (-4.1, -6.5 and -2.5kg) for the three female participants and -6.8±1.7kg for the male participants. Individual fat-free weight changed by a smaller amount overall: (0.13, 2.5 and -1.8kg) for the three female participants; -1.8±2.0kg for the male participants who, with one exception, lost fat-free tissue All participants showed a substantial variation in fat-free tissue weight during the expedition. Analysis of the daily energy expenditure showed adequate nutrition but the intake fell for the second part of the expedition although the reasons for this are unclear, but adaptation to the cold, altitude and workload are possible explanations. The validity of this time-averaged measurement for individual participants was determined from analysing moments about the mean of timeseries actigraphy data from wrist worn devices. The mean and autocorrelation function of the actigraphy data across subjects were analysed to determine whether measures could be compared between participants. The first, second and third moment about the mean of the day-to-day activity was found to be time-invariant for individual subjects (χ2, p>0.05) and the normalized mean and autocorrelation measured over a day for each participant
  • Role of Coriolis flow measurement technology in validation of model of syringe driver performance

    Clarkson, Douglas; Medical and Dental; D.M. Clarkson, M. Tshangini (Elsevier, 2024)
    The development of a flow/pressure measurement system in association with Bronkhorst High-Tech B.V. incorporating a Coriolis flow transducer, provided an opportunity to observe the flow/pressure dynamics of syringe drivers. A model of flow/pressure performance of syringe drivers was established where key variable factors included the compliance of the connected system and the associated line resistance. It was identified that the flow/pressure dynamics observed with the flow measurement system incorporating the Coriolis transducer matched that of the model. In this consideration the dominant compliance contribution related to that of the syringe. The model operates by considering the notional volume change in the residual fluid volume in the syringe with inflow from stepper motor action and outflow in the interval between sequential pulses. While many of the observations in the literature of syringe driver function are qualitative, the model allows a more precise prediction of associated device performance.
  • Socioeconomic and ethnic disparities associated with access to cochlear implantation for severe-to-profound hearing loss: A multicentre observational study of UK adults.

    Swords, Chloe; Ghedia, Reshma; Blanchford, Hannah; Arwyn-Jones, James; Heward, Elliot; Milinis, Kristijonas; Hardman, John; Smith, Matthew E; Bance, Manohar; Muzaffar, Jameel; et al. (PLoS Medicine, 2024-04-04)
    No Abstract
  • Estimation of infant radiation exposure from ingestion of breastmilk after SeHCAT capsule administration

    Rowley, Lisa; Medical and Dental; Comber, E.A., Adesanya, O., Gladstone, J., Coleclough, S., Rowley, L., (Lippincott, Williams & Wilkins, 2023-01-31)
    im: Assessment of the imaging properties of 3D-printable materials using dual energy computed tomography (DECT) to match clinical values for imaging phantoms. Methods: 3D-printed samples were imaged using DECT. Regions of interest were analyzed to assess spectral computed tomography (CT) numbers at various energies and measure the electron density (ρe) and effective atomic number (Zeff). Results: Electron density was proportional to the CT number for the materials assessed with Zeff between 6.43 and 7.01. The measured CT number increased with monochromatic energy for all but one sample. Conclusion: A single DECT scan provides valuable information regarding the properties of 3D-printable material due to the ease of measurement of ρe and Zeff. The majority of 3D-printed materials analyzed behaved like adipose tissue across a range of energies in CT imaging.
  • The Role of Far-UVC in Dentistry

    Clarkson, Douglas; Medical and Dental; Clarkson DM (Dent Update, 2024-02)
    No Abstract