Recent Submissions

  • Environmental effect of air versus gas tamponade in the management of rhegmatogenous retinal detachment VR surgery: A multicentre study of 3,239 patients.

    Moussa, George; Andreatta, Walter; Ch'ng, Soon; Ziaei, Hadi; Jalil, Assad; Patton, Niall; Ivanova, Tsveta; Lett, Kim Son; Park, Dong Young; Moussa, George; et al. (Public Library of Science, 2022-01-26)
    Purpose: To report the potential reduction of carbon emissions by utilising air-tamponade (AT), where possible, instead of fluorinated gases in the management of rhegmatogenous retinal detachment (RRD). We compared the carbon CO2 emissions produced at two large tertiary referral vitreoretinal (VR) centres where RRD are exclusively repaired using fluorinated gases to a tertiary VR mass of each gas used according to the Intergovernmental Panel on Climate Change. Materials and methods: Retrospective, continuous, comparative multicentre study of all procedures using fluorinated gases between 01/01/17-31/12/20 at the Manchester Royal Eye Hospital (MREH) and Birmingham and Midland Eye Centre (BMEC), and between 01/01/19-31/12/2020 at the University Hospitals Coventry and Warwickshire (UHCW). Results: We report on 3,239 (SF6:1,415 [43.7%], C2F6:1,235 [38.1%], C3F8:541 [16.7%], Air:48 [1.5%]) procedures. UHCW and BMEC utilise single use 30ml and 75ml cannisters, respectively and MREH use multi-use gas cylinders. UHCW used AT in 48 (70%) of RRD repairs. Mean equivalent mass CO2/patient was MREH:115.9kg, BMEC:7.9kg and UHCW:1.9kg. If assuming all centres used 30ml cannisters, the mean equivalent mass CO2/patient was MREH:3.5 kg, BMEC:3.1kg and UHCW:1.9kg. AT enabled UHCW to greatly reduce the need for the most environmentally damaging SF6 gas, leading to lower CO2 emissions by 47.0% and 41.1% compared to MREH and BMEC, respectively. Conclusion: We demonstrate how AT vs. the fluorinated gases can reduce in carbon footprint in the management of RRD. Further studies are required to determine the most 'environment-friendly' intraocular tamponade without compromising patient outcomes centre that also routinely employs AT in selected RRD cases.
  • One-stop laser clinics: patients' preferences for treatment.

    Jones, Lynval; Sampat, Venkatadri; Pagliarini, Sergio; Pagliarini, Sergio; Surgical Services; Medical and Dental (Wiley, 2003)
    No abstract available
  • Zonular dialysis and vitreous loss with a J-shaped hydrodissection cannula during phacoemulsification.

    Munshi, Vineeta; Sampat, Venkatadri; Pagliarini, Sergio; Pagliarini, Sergio; Munshi, Vineeta; Sampat, Venkatadri; Surgical Services; Medical and Dental (Wolters Kluwer, 2005)
    We report a complication that occurred during clear corneal phacoemulsification. When saline was injected during hydrodissection with a 27-gauge J-shaped cannula attached to a 2.0 mL luer-lock polypropylene syringe, the cannula dislodged and slipped behind the iris, hooking to the lens equator. Although the cannula was carefully removed, 3 clock hours of zonular dialysis were observed between the 4 o'clock and 7 o'clock meridians. After phacoemulsification, lens aspiration, and in-the-bag intraocular lens implantation, vitreous was noted inferiorly and the anterior vitrectomy was completed.
  • A case of gonococcal kerato-conjunctivitis mimicking orbital cellulitis.

    Hegde, Vijay; Smith, George; Choi, Jessie; Pagliarini, Sergio; Pagliarini, Sergio; Hegde, Vijay; Surgical Services; Medical and Dental (Wiley, 2005)
    Comment on The clinical characteristics and course of adult gonococcal conjunctivitis. Wan WL, Farkas GC, May WN, Robin JB. Am J Ophthalmol. 1986 Nov 15;102(5):575-83. doi: 10.1016/0002-9394(86)90527-1. PMID: 3777076
  • The effect of phacoemulsification cataract surgery on the measurement of retinal nerve fiber layer thickness using optical coherence tomography.

    El-Ashry, Mohamed; Appaswamy, Shivashankar; Deokule, Sunil; Pagliarini, Sergio; Pagliarini, Sergio; El-Ashry, Mohamed; Surgical Services; Medical and Dental (Taylor and Francis Group, 2006)
    To evaluate whether the measurement of retinal nerve fiber layer (RNFL) thickness using optical coherence tomography (OCT) changes after cataract surgery.
  • Erratum.

    Pagliarini, Sergio; Pagliarini, Sergio; Surgical Services; Medical and Dental (Taylor and Francis Group, 2014-09-22)
    Analysis of macular thickness in British population using optical coherence tomography (OCT): an emphasis on interocular symmetry. El-Ashry M, Hegde V, James P, Pagliarini S. Curr Eye Res. 2008 Aug;33(8):693-9. doi: 10.1080/02713680802323140. PMID: 18696345
  • Analysis of macular thickness in British population using optical coherence tomography (OCT): an emphasis on interocular symmetry.

    El-Ashry, Mohamed; Hegde, Vijay; James, Peter; Pagliarini, Sergio; Pagliarini, Sergio; Surgical Services; Medical and Dental (Taylor and Francis Group, 2008)
    To evaluate macular thickness measurements in normal subjects from British origin, to assess interocular asymmetry using optical coherence tomography (OCT) and to establish standard values for macular and foveal thickness
  • A case report of orbital haemorrhage associated with endoscopic sinus surgery and reversible sight loss: a multidisciplinary approach to management.

    Sood, Vaneeta; Rejali, Darius; Stocker, Judith; Mehta, Purnima; Pagliarini, Sergio; Ahluwalia, Harpreet; Pagliarini, Sergio; Sood, Vaneeta; Rejali, Darius; Stocker, Judith; et al. (Taylor and Francis Group, 2013)
    We report a case of intraoperative orbital haemorrhage as a complication of endoscopic sinus surgery performed under general anaesthesia. Initial unilateral complete visual loss occurred, but recovered due to accurate and early diagnosis combined with urgent surgical intervention. This patient's case is reported to illustrate the importance of early recognition of clinical signs and how a stepwise approach to management can result in a favourable visual outcome. Moreover, the mechanisms and pathophysiology of visual loss due to orbital haemorrhage following endoscopic sinus surgery are discussed.
  • A 2-Year, Phase IV, Multicentre, Observational Study of Ranibizumab 0.5 mg in Patients with Neovascular Age-Related Macular Degeneration in Routine Clinical Practice: The EPICOHORT Study.

    Beatty, Stephen; Lipkova, Blandina; Perez-Salvador Garcia, Eduardo; Reynders, Stefaan; Gekkieva, Margarita; Si Bouazza, Abdelkader; Pilz, Stefan; Pagliarini, Sergio; Pagliarini, Sergio; Surgical Services; et al. (Hindawi, 2014-04-28)
    To assess the safety profile of ranibizumab 0.5 mg in patients with neovascular age-related macular degeneration (nAMD) in routine clinical practice. Methods. This 2-year, multicentre, observational study was conducted to capture real-world early practice and outcomes across Europe, shortly after European licensing of ranibizumab for nAMD. Being observational in nature, the study did not impose diagnostic/therapeutic interventions/visit schedule. Patients were to be treated as per the EU summary of product characteristics (SmPC) in effect during the study. Key outcome measures were incidence of selected adverse events (AEs), treatment exposure, bilateral treatment, compliance to the EU SmPC, and best-corrected visual acuity (BCVA) over 2 years. Results. 755 of 770 patients received treatment. Ranibizumab was generally well tolerated with low incidence of selected AEs (0%-1.9%). Patients received 6.2 (mean) injections and 133 patients received bilateral treatment over 2 years. Protocol deviation to treatment compliance was reported in majority of patients. The observed decline in mean BCVA (Month 12, +1.5; Month 24, -1.3 letters) may be associated with undertreatment as suggested by BCVA subgroup analysis. Conclusion. The EPICOHORT study conducted in routine clinical practice reinforces the well-established safety profile of ranibizumab in nAMD. In early European practice it appeared that the nAMD patients were undertreated.
  • Ranibizumab 0.5 mg for Diabetic Macular Edema with Bimonthly Monitoring after a Phase of Initial Treatment: 18-Month, Multicenter, Phase IIIB RELIGHT Study.

    Pearce, Ian; Banerjee, Sanjiv; Burton, Ben J L; Chakravarthy, Usha; Downey, Louise; Gale, Richard P; Gibson, Jonathan; Patel, Jignesh; Sivaprasad, Sobha; Andrews, Chris; et al. (Elsevier, 2015-07-03)
    To evaluate ranibizumab 0.5 mg using bimonthly monitoring and individualized re-treatment after monthly follow-up for 6 months in patients with visual impairment due to diabetic macular edema (DME).
  • Analysis of Retinal Segmentation Changes at High Altitude With and Without Acetazolamide

    Clarke, Alexander Kenneth; Imray, Christopher Henry Ernest; Wright, Alex; Pagliarini, Sergio; imray, chris; Cozzi, Mariano; Pagliarini, Sergio; imray, chris; Cozzi, Mariano; Surgical Services; et al. (Association for Research in Vision and Ophthalmology, 2019-01)
    Our aim was to assess retinal venous diameter and segmented retinal layer thickness variation in acute systemic hypoxia with and without acetazolamide and to relate these changes to high altitude headache (HAH), as a proxy for intracerebral pathophysiology.
  • Susac's syndrome: the value of fundus fluorescein angiography.

    Pagliarini, Sergio; Allroggen, Holger; Khan, Imran Joseph; Pagliarini, Sergio; Allroggen, Holger; Khan, Imran Joseph; Surgical Services; Trauma and Neuro Services; Medical and Dental (BMJ Publishing Group, 2014-10-03)
    A 19-year-old woman presented with a 4-week history of headache, ataxia, vertigo, confusion, intermittent blurred vision in the right eye and intermittent hearing loss. MRI revealed white matter lesions and 'pepper pot' lesions of the corpus callosum. The cerebrospinal fluid had raised protein and lymphocytes. Fundal examination revealed multiple peripheral arterial occlusions in the both eyes confirmed with fundus fluorescein angiography (FFA). A diagnosis of Susac's syndrome was made. The patient was initially treated with steroids, followed by azathioprine and intravenous immunoglobulins (IVIg). Clinical improvement was noted, associated with improvement of the retinal circulation on FFA.
  • Retinoschisis Microstructure Visualization With En Face Spectral Domain Optical Coherence Tomography.

    Pagliarini, Sergio; Cozzi, Mariano; Pagliarini, Sergio; Cozzi, Mariano; Surgical Services; Medical and Dental (Wolters Kluwer, 2016)
    No abstract available
  • Diabetic maculopathy: multicolour and SD-OCT versus fundus photography.

    Kousha, Obaid; Delle Fave, Martina Maria; Cozzi, Mariano; Carini, Elisa; Pagliarini, Sergio; Pagliarini, Sergio; Surgical Services; Medical and Dental (BMJ Publishing Group, 2021-02-19)
    The English Diabetic Eye Screening (DES) programme recommends patients with M1 diabetic maculopathy to be referred to hospital eye services. DES uses flash fundus photography as the reference standard for maculopathy grading. We compared multicolour versus non-stereoscopic fundus photography at identifying M1 maculopathy, with spectral domain optical coherence tomography (SD-OCT) identifying macular thickening.
  • Incomplete Retinal Pigment Epithelial and Outer Retinal Atrophy in Age-Related Macular Degeneration: Classification of Atrophy Meeting Report 4.

    Guymer, Robyn H; Rosenfeld, Philip J; Curcio, Christine A; Holz, Frank G; Staurenghi, Giovanni; Freund, K Bailey; Schmitz-Valckenberg, Steffen; Sparrow, Janet; Spaide, Richard F; Tufail, Adnan; et al. (Elsevier, 2019-09-30)
    To describe the defining features of incomplete retinal pigment epithelium (RPE) and outer retinal atrophy (iRORA), a consensus term referring to the OCT-based anatomic changes often identified before the development of complete RPE and outer retinal atrophy (cRORA) in age-related macular degeneration (AMD). We provide descriptive OCT and histologic examples of disease progression.
  • To evaluate the efficacy of diagnostic periocular punch biopsy: using a 4-mm dermatology punch.

    Burgess, Nada R.; Rathore, Deepa; Gao, Anna; Johnson, Andria; Ahluwalia, Harpreet; Gao, Anna; Ophthalmology; Medical and Dental; University Hospitals Coventry and Warwickshire NHS Trust; South Warwickshire University NHS Foundation Trust; Aston University (Lippincott, Williams & Wilkins, 2023-01-18)
    Purpose: The dermatological punch biopsy is a minimally invasive procedure that provides conclusive diagnosis when managing periocular lesions. It aids with establishing histological diagnosis and subtype thereby facilitating management planning and eliminates the risk of unnecessary tissue sacrifice. The present literature provides limited evidence evaluating the value of punch biopsy in diagnosing periocular lesions. Methods: A retrospective case note analysis of 400 consecutive 4-mm periocular punch biopsies performed between 2005 and 2016, from 353 patients was undertaken at a single institution. Three hundred fifty-nine lesions had an initial definite clinical diagnosis of malignancy (group A) and the remaining 41 lesions had an uncertain clinical diagnosis with enough suspicion to merit a biopsy (group B). Results: In group A, 75.5% (n = 271) of the biopsies verified the clinical diagnosis of malignancy and 24.5% (n = 88) were benign. In group B, 70.7% (n = 29) of the lesions were benign and 29.3% (n = 12) were malignant and were subsequently treated as group A. Only 4, group A biopsies, which underwent formal excision, did not initially diagnose a malignancy (punch biopsy was repeated) providing a sensitivity of 98.6% and a specificity of 100%. One hundred seventeen were found to be benign avoiding unnecessary tissue sacrifice in 29.25% of cases. Conclusion: Our study provides the largest sample size in the literature that evaluates a 4-mm diagnostic periocular punch biopsy in managing eyelid lesions. In 29.5% of punch biopsies, unnecessary tissue sacrifice was avoided as they were histologically benign. The authors found that punch biopsies for lesions <7 mm carry a risk of inadvertent excision of lesion.