Novel impedance-pH parameters in pre-bariatric assessment of patients : a pilot study
Author
Gagliardi, MarioSantonicola, Antonella
Palma, Rossella
Angrisani, Luigi
Trudgill, Nigel
Iovino, Paola
Affiliation
University of Salerno; University of Rome; University of Naples; Sandwell and West Birmingham NHS TrustPublication date
2023-01-25
Metadata
Show full item recordAbstract
Novel impedance-pH parameters, Mean Nocturnal Baseline Impedance (MNBI) and Post-Reflux Swallow-Induced Peristaltic Wave (PSPW) index, have been proposed to improve the gastro-esophageal reflux disease (GERD) diagnostic yield. This study aims to determine the integrity of the esophageal epithelial barrier and chemical clearance using these novel parameters and to correlate them with acid exposure time (AET) and acid clearance time (ACT) in obese patients who are candidates for bariatric surgery (BS). Twenty impedance-pHmetry tracings of patients prior to BS were reviewed. Nine (45%) patients with a conclusive diagnosis of GERD had significantly higher ACT, lower MNBI in the distal esophagus and lower PSPW indexes compared to obese patients without GERD. Moreover, 100% of obese patients with GERD had a pathological ACT compared to obese patients without GERD (p = 0.003). However, the percentage of pathological MNBI and PSPW index did not differ between obese patients with and without GERD. The PSPW index and MNBI of the distal channel significantly correlated with ACT and AET. Further studies are needed to assess the role of time-consuming novel parameters in the routine evaluation of morbidly obese patients candidates for BS. The value of acid clearance time is confirmed as a relevant impedance-pH parameter in these patients.Citation
Gagliardi M, Santonicola A, Palma R, Angrisani L, Trudgill NJ, Iovino P. Novel Impedance-pH Parameters in Pre-Bariatric Assessment of Patients: A Pilot Study. J Clin Med. 2023 Jan 25;12(3):940. doi: 10.3390/jcm12030940Type
ArticlePMID
36769588Journal
Journal of Clinical MedicinePublisher
MDPIae974a485f413a2113503eed53cd6c53
10.3390/jcm12030940