Hypoxia is not the primary mechanism contributing to exercise-induced proteinuria.
Author
Joyce, Kelsley EDelamere, John
Bradwell, Susie
Myers, Stephen David
Ashdown, Kimberly
Rue, Carla
Lucas, Samuel Je
Thomas, Owen D
Fountain, Amy
Edsell, Mark
Myers, Fiona
Malein, Will
Clarke, Alex
Lewis, Chrisopher T
Newman, Charles
Johnson, Brian
Cadigan, Patrick
Wright, Alexander
Bradwell, Arthur
imray, chris
Publication date
2020-03-26Subject
Diseases & disorders of systemic, metabolic or environmental originHuman physiology
Sports medicine
Metadata
Show full item recordAbstract
With placebo, post-exercise α1-AGP levels were similar at sea level and altitude. Odds ratio (OR) for increased resting α1-AGP at altitude versus sea level was greater without losartan (2.16 times greater). At altitude, OR for reduced post-exercise α1-AGP (58% lower) was higher with losartan than placebo (2.25 times greater, p=0.059) despite similar pulse oximetry (SpO2) (p=0.95) between groups. Acetazolamide reduced post-exercise proteinuria by approximately threefold (9.3±9.7 vs 3.6±6.0 μg/min; p=0.025) although changes were not correlated (r=-0.10) with significant improvements in SpO2 (69.1%±4.5% vs 75.8%±3.8%; p=0.001).Citation
BMJ Open Sport Exerc Med . 2020 Mar 26;6(1):e000662Type
ArticleAdditional Links
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173992/https://bmjopensem.bmj.com/content/6/1/e000662
PMID
32341794Publisher
BMJ Publishing Groupae974a485f413a2113503eed53cd6c53
10.1136/bmjsem-2019-000662