Cerebral venous system and anatomical predisposition to high-altitude headache.
Author
Wilson, Mark HDavagnanam, Indran
Holland, Graeme
Dattani, Raj S
Tamm, Alexander
Hirani, Shashivadan P
Kolfschoten, Nicky
Strycharczuk, Lisa
Green, Cathy
Thornton, John S
Wright, Alex
Edsell, Mark
Kitchen, Neil D
Sharp, David J
Ham, Timothy E
Murray, Andrew
Holloway, Cameron J
Clarke, Kieran
Grocott, Mike P W
Montgomery, Hugh
imray, chris
Publication date
2013-02-26
Metadata
Show full item recordAbstract
Objective: As inspired oxygen availability falls with ascent to altitude, some individuals develop high-altitude headache (HAH). We postulated that HAH results when hypoxia-associated increases in cerebral blood flow occur in the context of restricted venous drainage, and is worsened when cerebral compliance is reduced. We explored this hypothesis in 3 studies.Citation
Wilson MH, Davagnanam I, Holland G, Dattani RS, Tamm A, Hirani SP, Kolfschoten N, Strycharczuk L, Green C, Thornton JS, Wright A, Edsell M, Kitchen ND, Sharp DJ, Ham TE, Murray A, Holloway CJ, Clarke K, Grocott MP, Montgomery H, Imray C; Birmingham Medical Research Expeditionary Society and Caudwell Xtreme Everest Research Group. Cerebral venous system and anatomical predisposition to high-altitude headache. Ann Neurol. 2013 Mar;73(3):381-9. doi: 10.1002/ana.23796. Epub 2013 Feb 26.Type
ArticlePMID
23444324Journal
Annals of NeurologyPublisher
Wileyae974a485f413a2113503eed53cd6c53
10.1002/ana.23796