Pain in individuals with idiopathic inflammatory myopathies, other systemic autoimmune rheumatic diseases, and without rheumatic diseases : a report from the COVAD study
Author
Shinjo, Samuel KatsuyukiKim, Minchul
Hoff, Leonardo Santos
Missé, Rafael Giovani
Sen, Parikshit
Naveen, R
Day, Jessica
Cordeiro, Rafael Alves
Júnior, Jucier Gonçalves
Chatterjee, Tulika
Lilleker, James B
Agarwal, Vishwesh
Kardes, Sinan
Milchert, Marcin
Gheita, Tamer
Salim, Babur
Velikova, Tsvetelina
Gracia-Ramos, Abraham Edgar
Parodis, Ioannis
O'Callaghan, Albert Selva
Nikiphorou, Elena
Makol, Ashima
Tan, Ai Lyn
Cavagna, Lorenzo
Saavedra, Miguel A
Ziade, Nelly
Knitza, Johannes
Kuwana, Masataka
Nune, Arvind
Distler, Oliver
Chinoy, Hector
Agarwal, Vikas
Aggarwal, Rohit
Gupta, Latika
Affiliation
Universidade de Sao Paulo; University of Illinois College of Medicine Peoria; Universidade Potiguar (UnP); Sandwell and West Birmingham NHS Trust; et al.Publication date
2023-03-05Subject
Rheumatology
Metadata
Show full item recordAbstract
Objectives: To compare pain intensity among individuals with idiopathic inflammatory myopathies (IIMs), other systemic autoimmune rheumatic diseases (AIRDs), and without rheumatic disease (wAIDs). Methods: Data were collected from the COVID-19 Vaccination in Autoimmune Diseases (COVAD) study, an international cross-sectional online survey, from December 2020 to August 2021. Pain experienced in the preceding week was assessed using numeral rating scale (NRS). We performed a negative binomial regression analysis to assess pain in IIMs subtypes and whether demographics, disease activity, general health status, and physical function had an impact on pain scores. Results: Of 6988 participants included, 15.1% had IIMs, 27.9% had other AIRDs, and 57.0% were wAIDs. The median pain NRS in patients with IIMs, other AIRDs, and wAIDs were 2.0 (interquartile range [IQR] = 1.0-5.0), 3.0 (IQR = 1.0-6.0), and 1.0 (IQR = 0-2.0), respectively (P < 0.001). Regression analysis adjusted for gender, age, and ethnicity revealed that overlap myositis and antisynthetase syndrome had the highest pain (NRS = 4.0, 95% CI = 3.5-4.5, and NRS = 3.6, 95% CI = 3.1-4.1, respectively). An additional association between pain and poor functional status was observed in all groups. Female gender was associated with higher pain scores in almost all scenarios. Increasing age was associated with higher pain NRS scores in some scenarios of disease activity, and Asian and Hispanic ethnicities had reduced pain scores in some functional status scenarios. Conclusion: Patients with IIMs reported higher pain levels than wAIDs, but less than patients with other AIRDs. Pain is a disabling manifestation of IIMs and is associated with a poor functional status.Citation
Shinjo SK, Kim M, Hoff LS, Missé RG, Sen P, Naveen R, Day J, Cordeiro RA, Júnior JG, Chatterjee T, Lilleker JB, Agarwal V, Kardes S, Milchert M, Gheita T, Salim B, Velikova T, Gracia-Ramos AE, Parodis I, O'Callaghan AS, Nikiphorou E, Makol A, Tan AL, Cavagna L, Saavedra MA, Ziade N, Knitza J, Kuwana M, Nune A, Distler O, Chinoy H, Agarwal V, Aggarwal R, Gupta L; COVAD Study Group. Pain in individuals with idiopathic inflammatory myopathies, other systemic autoimmune rheumatic diseases, and without rheumatic diseases: A report from the COVAD study. Int J Rheum Dis. 2023 Apr;26(4):727-739. doi: 10.1111/1756-185X.14636Type
ArticlePMID
36872076Publisher
Wileyae974a485f413a2113503eed53cd6c53
10.1111/1756-185X.14636