Monotherapy treatment of epilepsy in pregnancy: congenital malformation outcomes in the child.
Bromley, Rebecca Adab, Naghme Bluett-Duncan, Matt Clayton-Smith, Jill Christensen, Jakob Edwards, Katherine Greenhalgh, Janette Hill, Ruaraidh A Jackson, Cerian F Khanom, Sonia
Bromley, Rebecca
Adab, Naghme
Bluett-Duncan, Matt
Clayton-Smith, Jill
Christensen, Jakob
Edwards, Katherine
Greenhalgh, Janette
Hill, Ruaraidh A
Jackson, Cerian F
Khanom, Sonia
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Publication date
2023-08-29
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Abstract
Background: Prenatal exposure to certain anti-seizure medications (ASMs) is associated with an increased risk of major congenital malformations (MCM). The majority of women with epilepsy continue taking ASMs throughout pregnancy and, therefore, information on the potential risks associated with ASM treatment is required.
Objectives: To assess the effects of prenatal exposure to ASMs on the prevalence of MCM in the child.
Citation
Cochrane Database Syst Rev . 2023 Aug 29;8(8):CD010224
Type
Evidence Summary