Propranolol ameliorates the antifungal activity of azoles in invasive candidiasis
Author
Mayandi, VenkateshKang, Wen-Tyng
Ting, Darren Shu Jeng
Goh, Eunice Tze Leng
Lynn, Myoe Naing
Aung, Thet Tun
Vadivelu, Jamuna
Barathi, Veluchamy Amutha
Chan, Anita Sook Yee
Lakshminarayanan, Rajamani
Affiliation
Singapore Eye Research Institute; Duke-NUS Graduate Medical School; University of Malaya; Sandwell and West Birmingham NHS Trust; et al.Publication date
2023-03-23Subject
Ophthalmology
Metadata
Show full item recordAbstract
The effectiveness of current antifungal therapies is hampered by the emergence of drug resistance strains, highlighting an urgent need for new alternatives such as adjuvant antifungal treatments. This study aims to examine the synergism between propranolol and antifungal drugs, based on the premise that propranolol is known to inhibit fungal hyphae. In vitro studies demonstrate that propranolol potentiates the antifungal activity of azoles and that the effect is more pronounced for propranolol-itraconazole combination. Using an in vivo murine systemic candidemia model, we show that propranolol-itraconazole combination treatment resulted in a lower rate of body weight loss, decreased kidney fungal bioburden and renal inflammation when compared to propranolol and azole treatment alone or untreated control. Altogether, our findings suggest that propranolol increases the efficacy of azoles against C. albicans, offering a new therapeutic strategy against invasive fungal infections.Citation
Mayandi V, Kang WT, Ting DSJ, Goh ETL, Lynn MN, Aung TT, Vadivelu J, Barathi VA, Chan ASY, Lakshminarayanan R. Propranolol Ameliorates the Antifungal Activity of Azoles in Invasive Candidiasis. Pharmaceutics. 2023 Mar 23;15(4):1044. doi: 10.3390/pharmaceutics15041044Type
ArticlePMID
37111530Journal
PharmaceuticsPublisher
MDPIae974a485f413a2113503eed53cd6c53
10.3390/pharmaceutics15041044