Diabetes and Endocrinology
Recent Submissions
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All-cause mortality in type 2 diabetes : it’s all about the eGFR and not the serum creatinineA Clinical Digest piece reviewing cardiovascular journal articles.
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A mixed bag of ideas for CVD risk reduction and finding diabetes in the vascular clinicA Clinical Digest piece reviewing cardiovascular and major journal articles.
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Cardiovascular outcomes trials for glucose-lowering therapies : what do the results mean for practice?DigestDEBATE: In this section, a panel of multidisciplinary team members give their opinions on a recently published paper. In this issue, we discuss the outcome of the cardiovascular safety trial of empagliflozin, and what the results mean for clinical practice in the UK.
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Hypoglycaemia, CVD risk and mortality : a reminder of some Latin, ethical principles and patient safetyA Clinical Digest piece reviewing diabetes journal articles.
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The metabolic syndrome? Time to reconsider its clinical usefulnessA Clinical Digest piece reviewing diabetes journal articles.
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Low maternal vitamin B12 status is associated with lower cord blood HDL cholesterol in white Caucasians living in the UKBackground and aims: Studies in South Asian population show that low maternal vitamin B12 associates with insulin resistance and small for gestational age in the offspring. Low vitamin B12 status is attributed to vegetarianism in these populations. It is not known whether low B12 status is associated with metabolic risk of the offspring in whites, where the childhood metabolic disorders are increasing rapidly. Here, we studied whether maternal B12 levels associate with metabolic risk of the offspring at birth. Methods: This is a cross-sectional study of 91 mother-infant pairs (n = 182), of white Caucasian origin living in the UK. Blood samples were collected from white pregnant women at delivery and their newborns (cord blood). Serum vitamin B12, folate, homocysteine as well as the relevant metabolic risk factors were measured. Results: The prevalence of low serum vitamin B12 (<191 ng/L) and folate (<4.6 μg/L) were 40% and 11%, respectively. Maternal B12 was inversely associated with offspring's Homeostasis Model Assessment 2-Insulin Resistance (HOMA-IR), triglycerides, homocysteine and positively with HDL-cholesterol after adjusting for age and BMI. In regression analysis, after adjusting for likely confounders, maternal B12 is independently associated with neonatal HDL-cholesterol and homocysteine but not triglycerides or HOMA-IR. Conclusions: Our study shows that low B12 status is common in white women and is independently associated with adverse cord blood cholesterol.
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Xultophy : combination therapy for the treatment of type 2 diabetesXultophy is the first product to combine a basal insulin and an incretin mimetic for the treatment of type 2 diabetes. Here Steve Chaplin presents the clinical data relating to its efficacy and adverse events and Vinod Patel outlines its place in therapy.
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Type 2 diabetes : pharmacological management strategiesCurrent and future treatment options for the management of patients with type 2 diabetes. In this article you will learn: The current pharmacological strategies for management of patients with type 2 diabetes The status of newer therapies targeting the incretin axis and renal glucose handling The status of newer, longer-acting insulins
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The outcome of dapagliflozin use in a real-life clinical setting in multi-district general hospitalsPoster abstract P470 in the section 'Clinical care and other categories posters' of the Diabetes UK Professional Conference 2015, ExCeL London, 11–13 March 2015.
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Low breastfeeding rates in women with high risk of gestational diabetes : differences between South Asians and CaucasiansPoster abstract P493 in the section 'Clinical care and other categories posters' of the Diabetes UK Professional Conference 2015, ExCeL London, 11–13 March 2015.
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An audit looking at general practitioner (GP) referrals of adult patients with diabetes undergoing surgeryPoster abstract P258 in the section 'Clinical care and other categories posters' of the Diabetes UK Professional Conference 2015, ExCeL London, 11–13 March 2015.
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Predictors of prematurity in metformin-treated gestational diabetes (GDM)Poster abstract P498 in the section 'Clinical care and other categories posters' of the Diabetes UK Professional Conference 2015, ExCeL London, 11–13 March 2015.
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Maternal homocysteine levels at the time of diagnosis independently predict small-for-gestational-age (SGA) infants in gestational diabetes (GDM)Poster abstract P495 in the section 'Clinical care and other categories posters' of the Diabetes UK Professional Conference 2015, ExCeL London, 11–13 March 2015.
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Effects of maternal diabetes and body mass index (BMI) on offspring birth weight vary across ethnic groupsPoster abstract P164 in the section 'Basic and clinical science posters' of the Diabetes UK Professional Conference 2015, ExCeL London, 11–13 March 2015.
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Antenatal customised growth charts overestimate offspring birth weight in gestational diabetesPoster abstract P162 in the section 'Basic and clinical science posters' of the Diabetes UK Professional Conference 2015, ExCeL London, 11–13 March 2015.
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Early ethnic differences in fetal growth patterns in gestational diabetes (GDM)Poster abstract P161 in the section 'Basic and clinical science posters' of the Diabetes UK Professional Conference 2015, ExCeL London, 11–13 March 2015.
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Low vitamin B12 in pregnancy is associated with maternal obesity and gestational diabetesPoster abstract P159 in the section 'Basic and clinical science posters' of the Diabetes UK Professional Conference 2015, ExCeL London, 11–13 March 2015.
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Time to stress those new year’s resolutions again!A Clinical Digest piece reviewing cardiovascular and major journal articles.
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The edict from DCCT/EDIC : reducing the risk of cardiovascular disease in people with type 1 diabetesA Clinical Digest piece reviewing diabetes journal articles.
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Preventing death, CVD and renal complications in type 1 patients : the triple shieldA Clinical Digest piece reviewing diabetes journal articles.