High fatigue scores in patients with idiopathic inflammatory myopathies : a multigroup comparative study from the COVAD e-survey
Author
Grignaschi, SilviaKim, Minchul
Zanframundo, Giovanni
Ravichandran, Naveen
Lilleker, James B
Sen, Parikshit
Joshi, Mrudula
Agarwal, Vishwesh
Kardes, Sinan
Day, Jessica
Makol, Ashima
Milchert, Marcin
Gheita, Tamer
Salim, Babur
Velikova, Tsvetelina
Gracia-Ramos, Abraham Edgar
Parodis, Ioannis
Nikiphorou, Elena
Chatterjee, Tulika
Tan, Ai Lyn
Saavedra, Miguel A
Shinjo, Samuel Katsuyuki
Ziade, Nelly
Knitza, Johannes
Kuwana, Masataka
Nune, Arvind
Distler, Oliver
Chinoy, Hector
Cavagna, Lorenzo
Agarwal, Vikas
Aggarwal, Rohit
Gupta, Latika
Affiliation
University of Pavia; IRCCS Policlinico San Matteo Foundation; University of Illinois College of Medicine Peoria; Sandwell and West Birmingham NHS Trust; et al.Publication date
2023-06-14Subject
Rheumatology
Metadata
Show full item recordAbstract
Idiopathic inflammatory myopathies (IIMs) confer a significant risk of disability and poor quality of life, though fatigue, an important contributing factor, remains under-reported in these individuals. We aimed to compare and analyze differences in visual analog scale (VAS) scores (0-10 cm) for fatigue (VAS-F) in patients with IIMs, non-IIM systemic autoimmune diseases (SAIDs), and healthy controls (HCs). We performed a cross-sectional analysis of the data from the COVID-19 Vaccination in Autoimmune Diseases (COVAD) international patient self-reported e-survey. The COVAD survey was circulated from December 2020 to August 2021, and details including demographics, COVID-19 history, vaccination details, SAID details, global health, and functional status were collected from adult patients having received at least one COVID-19 vaccine dose. Fatigue experienced 1 week prior to survey completion was assessed using a single-item 10 cm VAS. Determinants of fatigue were analyzed in regression models. Six thousand nine hundred and eighty-eight respondents (mean age 43.8 years, 72% female; 55% White) were included in the analysis. The overall VAS-F score was 3 (IQR 1-6). Patients with IIMs had similar fatigue scores (5, IQR 3-7) to non-IIM SAIDs [5 (IQR 2-7)], but higher compared to HCs (2, IQR 1-5; P < 0.001), regardless of disease activity. In adjusted analysis, higher VAS-F scores were seen in females (reference female; coefficient -0.17; 95%CI -0.21 to -13; P < 0.001) and Caucasians (reference Caucasians; coefficient -0.22; 95%CI -0.30 to -0.14; P < 0.001 for Asians and coefficient -0.08; 95%CI -0.13 to 0.30; P = 0.003 for Hispanics) in our cohort. Our study found that patients with IIMs exhibit considerable fatigue, similar to other SAIDs and higher than healthy individuals. Women and Caucasians experience greater fatigue scores, allowing identification of stratified groups for optimized multidisciplinary care and improve outcomes such as quality of life.Citation
Grignaschi S, Kim M, Zanframundo G, Ravichandran N, Lilleker JB, Sen P, Joshi M, Agarwal V, Kardes S, Day J, Makol A, Milchert M, Gheita T, Salim B, Velikova T, Gracia-Ramos AE, Parodis I, Nikiphorou E, Chatterjee T, Tan AL, Saavedra MA, Shinjo SK, Ziade N, Knitza J, Kuwana M, Nune A, Distler O, Chinoy H, Cavagna L, Agarwal V, Aggarwal R, Gupta L; COVAD study group. High fatigue scores in patients with idiopathic inflammatory myopathies: a multigroup comparative study from the COVAD e-survey. Rheumatol Int. 2023 Sep;43(9):1637-1649. doi: 10.1007/s00296-023-05344-zType
ArticlePMID
37314497Journal
Rheumatology InternationalPublisher
Springerae974a485f413a2113503eed53cd6c53
10.1007/s00296-023-05344-z