A practical approach to small round cell tumors involving the gastrointestinal tract and abdomen
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Abstract
Small round cell neoplasms are diagnostically challenging owing to their clinical and pathologic overlap, necessitating use of large immunopanels and molecular analysis. Ewing sarcomas (ES) are the most common, but EWSR1 is translocated in several diverse neoplasms, some with round cell morphology. Molecular advances enable classification of many tumors previously termed 'atypical ES'. The current WHO Classification includes two new undifferentiated round cell sarcomas (with CIC or BCOR alterations), and a group of sarcomas in which EWSR1 partners with non-Ewing family transcription factor genes. This article reviews the spectrum of small round cell sarcomas within the gastrointestinal tract and abdomen.Citation
Thway K, Fisher C. A Practical Approach to Small Round Cell Tumors Involving the Gastrointestinal Tract and Abdomen. Surg Pathol Clin. 2023 Dec;16(4):765-778. doi: 10.1016/j.path.2023.05.012.Type
ArticleAdditional Links
http://www.sciencedirect.com/science/journal/18759181PMID
37863565Journal
Surgical Pathology ClinicsPublisher
Elsevierae974a485f413a2113503eed53cd6c53
10.1016/j.path.2023.05.012