International Consensus on post-transplantation diabetes mellitus
Author
Sharif, AdnanChakkera, Harini
de Vries, Aiko P J
Eller, Kathrin
Guthoff, Martina
Haller, Maria C
Hornum, Mads
Nordheim, Espen
Kautzky-Willer, Alexandra
Krebs, Michael
Kukla, Aleksandra
Kurnikowski, Amelie
Schwaiger, Elisabeth
Montero, Nuria
Pascual, Julio
Jenssen, Trond G
Porrini, Esteban
Hecking, Manfred
Publication date
2024-01-03
Metadata
Show full item recordAbstract
Post-transplantation diabetes mellitus (PTDM) remains a leading complication after solid organ transplantation. Previous international PTDM consensus meetings in 2003 and 2013 provided standardized frameworks to reduce heterogeneity in diagnosis, risk stratification and management. However, the last decade has seen significant advancements in our PTDM knowledge complemented by rapidly changing treatment algorithms for management of diabetes in the general population. In view of these developments, and to ensure reduced variation in clinical practice, a 3rd international PTDM Consensus Meeting was planned and held between 6-8 May 2022 in Vienna, Austria involving global delegates with PTDM expertise to update the previous report. This update includes opinion statements concerning optimal diagnostic tools, recognition of prediabetes (impaired fasting glucose and/or impaired glucose tolerance), new mechanistic insights, immunosuppression modification, evidence-based strategies to prevent PTDM, treatment hierarchy for incorporating novel glucose-lowering agents and suggestions for the future direction of PTDM research to address unmet needs. Due to the paucity of good quality evidence, consensus meeting participants agreed making GRADE recommendations would be flawed Although kidney-allograft centric, we suggest these opinion statements can be appraised by the transplantation community for implementation across different solid organ transplant cohorts. Acknowledging the paucity of published literature, this personal viewpoint reflects consensus expert opinion. Attaining evidence is desirable to ensure establishment of optimized care for any solid organ transplant recipient at risk of, or who develops, PTDM as we strive to improve long-term outcomes.Citation
Sharif A, Chakkera H, de Vries APJ, Eller K, Guthoff M, Haller MC, Hornum M, Nordheim E, Kautzky-Willer A, Krebs M, Kukla A, Kurnikowski A, Schwaiger E, Montero N, Pascual J, Jenssen TG, Porrini E, Hecking M. International Consensus on post-transplantation diabetes mellitus. Nephrol Dial Transplant. 2024 Jan 3:gfad258. doi: 10.1093/ndt/gfad258.Type
ArticlePMID
38171510Publisher
Oxford University Pressae974a485f413a2113503eed53cd6c53
10.1093/ndt/gfad258