A systematic review of optical coherence tomography findings in adults with mild traumatic brain injury.
Author
Lyons, Hannah SSassani, Matilde
Hyder, Yousef
Mitchell, James L
Thaller, Mark
Mollan, Susan P
Sinclair, Alexandra J
Blanch, Richard J
Publication date
2024-01-18Subject
Ophthalmology
Metadata
Show full item recordAbstract
Mild traumatic brain injury (mTBI) is common with many patients suffering disabling long-term sequelae, with visual symptoms frequently reported. There are no objective biomarkers of mTBI that are routinely used in clinical practice. Optical coherence tomography (OCT) has been used in mTBI research, as it enables visualisation of the neuroretina, allowing measurement of the retinal nerve fibre layer and ganglion cell layer. This systematic review aims to appraise the available literature and assess whether there are significant changes within the retinal nerve fibre layer and ganglion cell layer in subjects after mTBI. A systematic review was carried out in accordance with PRISMA guidelines and registered with PROSPERO (Number: CRD42022360498). Four databases were searched for relevant literature published from inception until 1 September 2022. Abstracts and full texts were screened by three independent reviewers. Initial screening of databases yielded 341 publications, of these, three fulfilled all the criteria for inclusion. All three studies showed thinning of the retinal nerve fibre layer, whereas there were no significant changes in the ganglion cell layer. This systematic review demonstrated that thinning of the retinal nerve fibre layer (but not of the ganglion cell layer) is associated with mTBI. It provides preliminary evidence for the use of the retinal nerve fibre layer as a potential biomarker of damage to the visual system in mTBI. Further prospective longitudinal studies ensuring uniform diagnosis and accurate phenotyping of mTBI are needed to understand the effects on the visual system and potential of OCT as a prognostic biomarker.Citation
Lyons HS, Sassani M, Hyder Y, Mitchell JL, Thaller M, Mollan SP, Sinclair AJ; mTBI Predict Consortium; Blanch RJ. A systematic review of optical coherence tomography findings in adults with mild traumatic brain injury. Eye (Lond). 2024 Jan 18. doi: 10.1038/s41433-023-02845-w.Type
ArticleAdditional Links
http://www.nature.com/eyePMID
38238577Journal
EyePublisher
Nature Publishing Groupae974a485f413a2113503eed53cd6c53
10.1038/s41433-023-02845-w