Consensus guideline for the diagnosis and management of pituitary adenomas in childhood and adolescence: Part 1, general recommendations
Author
Korbonits, MártaBlair, Joanne C
Boguslawska, Anna
Ayuk, John
Davies, Justin H
Druce, Maralyn R
Evanson, Jane
Flanagan, Daniel
Glynn, Nigel
Higham, Claire E
Jacques, Thomas S
Sinha, Saurabh
Simmons, Ian
Thorp, Nicky
Swords, Francesca M
Storr, Helen L
Spoudeas, Helen A
Publication date
2024-02-09
Metadata
Show full item recordAbstract
Tumours of the anterior part of the pituitary gland represent just 1% of all childhood (aged <15 years) intracranial neoplasms, yet they can confer high morbidity and little evidence and guidance is in place for their management. Between 2014 and 2022, a multidisciplinary expert group systematically developed the first comprehensive clinical practice consensus guideline for children and young people under the age 19 years (hereafter referred to as CYP) presenting with a suspected pituitary adenoma to inform specialist care and improve health outcomes. Through robust literature searches and a Delphi consensus exercise with an international Delphi consensus panel of experts, the available scientific evidence and expert opinions were consolidated into 74 recommendations. Part 1 of this consensus guideline includes 17 pragmatic management recommendations related to clinical care, neuroimaging, visual assessment, histopathology, genetics, pituitary surgery and radiotherapy. While in many aspects the care for CYP is similar to that of adults, key differences exist, particularly in aetiology and presentation. CYP with suspected pituitary adenomas require careful clinical examination, appropriate hormonal work-up, dedicated pituitary imaging and visual assessment. Consideration should be given to the potential for syndromic disease and genetic assessment. Multidisciplinary discussion at both the local and national levels can be key for management. Surgery should be performed in specialist centres. The collection of outcome data on novel modalities of medical treatment, surgical intervention and radiotherapy is essential for optimal future treatment.Citation
Korbonits M, Blair JC, Boguslawska A, Ayuk J, Davies JH, Druce MR, Evanson J, Flanagan D, Glynn N, Higham CE, Jacques TS, Sinha S, Simmons I, Thorp N, Swords FM, Storr HL, Spoudeas HA. Consensus guideline for the diagnosis and management of pituitary adenomas in childhood and adolescence: Part 1, general recommendations. Nat Rev Endocrinol. 2024 May;20(5):278-289. doi: 10.1038/s41574-023-00948-8. Epub 2024 Feb 9.Type
ArticlePMID
38336897Journal
Nature Reviews EndocrinologyPublisher
Nature Researchae974a485f413a2113503eed53cd6c53
10.1038/s41574-023-00948-8