Augmentation of natriuretic peptide (NP) receptor A and B (NPR-A and NPR-B) and cyclic guanosine monophosphate (cGMP) signalling as a therapeutic strategy in heart failure.
Author
Ajay ARasoul D
Abdullah A
Lee Wei En B
Mashida K
Al-Munaer M
Ajay H
Duvva D
Mathew J
Adenaya A
Lip GYH
Sankaranarayanan R
Affiliation
Liverpool University Hospitals NHS Foundation Trust; The Dudley Group NHS Foundation Trust; University of Liverpool, Liverpool et alPublication date
01/07/2023Subject
Cardiology
Metadata
Show full item recordAbstract
Heart failure is a complex, debilitating condition and despite advances in treatment, it remains a significant cause of morbidity and mortality worldwide. Therefore, the need for alternative treatment strategies is essential. In this review, we explore the therapeutic strategies of augmenting natriuretic peptide receptors (NPR-A and NPR-B) and cyclic guanosine monophosphate (cGMP) in heart failure. Areas Covered: We aim to provide an overview of the evidence of preclinical and clinical studies on novel heart failure treatment strategies. Papers collected in this review have been filtered and screened following PubMed searches. This includes epigenetics, modulating enzyme activity in natriuretic peptide (NP) synthesis, gene therapy, modulation of downstream signaling by augmenting soluble guanylate cyclase (sGC) and phosphodiesterase (PDE) inhibition, nitrates, c-GMP-dependent protein kinase, synthetic and designer NP and RNA therapy. Expert Opinion: The novel treatment strategies mentioned above have shown great potential, however, large randomized controlled trials are still lacking. The biggest challenge is translating the results seen in preclinical trials into clinical trials. We recommend a multi-disciplinary team approach with cardiologists, geneticist, pharmacologists, bioengineers, researchers, regulators, and patients to improve heart failure outcomes. Future management can involve telemedicine, remote monitoring, and artificial intelligence to optimize patient care.Citation
Ajay A, Rasoul D, Abdullah A, Lee Wei En B, Mashida K, Al-Munaer M, Ajay H, Duvva D, Mathew J, Adenaya A, Lip GYH, Sankaranarayanan R. Augmentation of natriuretic peptide (NP) receptor A and B (NPR-A and NPR-B) and cyclic guanosine monophosphate (cGMP) signalling as a therapeutic strategy in heart failure. Expert Opin Investig Drugs. 2023 Jul-Dec;32(12):1157-1170. doi: 10.1080/13543784.2023.2290064. Epub 2023 Dec 28. PMID: 38032188.Type
ArticlePMID
38032188Publisher
Taylor and Francis Groupae974a485f413a2113503eed53cd6c53
10.1080/13543784.2023.2290064