Effectiveness and safety of COVID-19 vaccines on maternal and perinatal outcomes: a systematic review and meta-analysis.
Author
Fernández-García, SilviaDel Campo-Albendea, Laura
Sambamoorthi, Dharshini
Sheikh, Jameela
Lau, Karen
Osei-Lah, Nana
Ramkumar, Anoushka
Naidu, Harshitha
Stoney, Nicole
Sundaram, Paul
Sengupta, Paulomi
Mehta, Samay
Attarde, Shruti
Maddock, Sophie
Manning, Millie
Meherally, Zainita
Ansari, Kehkashan
Lawson, Heidi
Yap, Magnus
Kew, Tania
Punnoose, Andriya
Knight, Chloe
Sadeqa, Eyna
Cherian, Jiya
Ravi, Sangamithra
Chen, Wentin
Walker, Kate
O'Donoghue, Keelin
van Wely, Madelon
van Leeuwen, Elizabeth
Kostova, Elena
Kunst, Heinke
Khalil, Asma
Brizuela, Vanessa
Kara, Edna
Kim, Caron Rahn
Thorson, Anna
Oladapo, Olufemi T
Mofenson, Lynne
Gottlieb, Sami L
Bonet, Mercedes
Moss, Ngawai
Zamora, Javier
Allotey, John
Thangaratinam, Shakila
Publication date
2024-04-04Subject
Obstetrics. Midwifery
Metadata
Show full item recordAbstract
Sixty-seven studies (1 813 947 women) were included. Overall, in test-negative design studies, pregnant women fully vaccinated with any COVID-19 vaccine had 61% reduced odds of SARS-CoV-2 infection during pregnancy (OR 0.39, 95% CI 0.21 to 0.75; 4 studies, 23 927 women; I2=87.2%) and 94% reduced odds of hospital admission (OR 0.06, 95% CI 0.01 to 0.71; 2 studies, 868 women; I2=92%). In adjusted cohort studies, the risk of hypertensive disorders in pregnancy was reduced by 12% (RR 0.88, 95% CI 0.82 to 0.92; 2 studies; 115 085 women), while caesarean section was reduced by 9% (OR 0.91, 95% CI 0.85 to 0.98; 6 studies; 30 192 women). We observed an 8% reduction in the risk of neonatal intensive care unit admission (RR 0.92, 95% CI 0.87 to 0.97; 2 studies; 54 569 women) in babies born to vaccinated versus not vaccinated women. In general, vaccination during pregnancy was not associated with increased risk of adverse pregnancy or perinatal outcomes. Pain at the injection site was the most common side effect reported (77%, 95% CI 52% to 94%; 11 studies; 27 195 women).Citation
Fernández-García S, Del Campo-Albendea L, Sambamoorthi D, Sheikh J, Lau K, Osei-Lah N, Ramkumar A, Naidu H, Stoney N, Sundaram P, Sengupta P, Mehta S, Attarde S, Maddock S, Manning M, Meherally Z, Ansari K, Lawson H, Yap M, Kew T, Punnoose A, Knight C, Sadeqa E, Cherian J, Ravi S, Chen W, Walker K, O'Donoghue K, van Wely M, van Leeuwen E, Kostova E, Kunst H, Khalil A, Brizuela V, Kara E, Kim CR, Thorson A, Oladapo OT, Mofenson L, Gottlieb SL, Bonet M, Moss N, Zamora J, Allotey J, Thangaratinam S; PregCOV-19 Living Systematic Review Consortium. Effectiveness and safety of COVID-19 vaccines on maternal and perinatal outcomes: a systematic review and meta-analysis. BMJ Glob Health. 2024 Apr 4;9(4):e014247. doi: 10.1136/bmjgh-2023-014247.Type
ArticleOther
Additional Links
https://www.ncbi.nlm.nih.gov/pmc/journals/3154/PMID
38580375Journal
BMJ Global HealthPublisher
BMJ Publishing Groupae974a485f413a2113503eed53cd6c53
10.1136/bmjgh-2023-014247