Consensus on diagnosis and management of Cushing's disease: a guideline update.
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Author
Fleseriu, MariaAuchus, Richard
Bancos, Irina
Ben-Shlomo, Anat
Bertherat, Jerome
Biermasz, Nienke R
Boguszewski, Cesar L
Bronstein, Marcello D
Buchfelder, Michael
Carmichael, John D
Casanueva, Felipe F
Castinetti, Frederic
Chanson, Philippe
Findling, James
Gadelha, Mônica
Geer, Eliza B
Giustina, Andrea
Grossman, Ashley
Gurnell, Mark
Ho, Ken
Ioachimescu, Adriana G
Kaiser, Ursula B
Karavitaki, Niki
Katznelson, Laurence
Kelly, Daniel F
Lacroix, André
McCormack, Ann
Melmed, Shlomo
Molitch, Mark
Mortini, Pietro
Newell-Price, John
Nieman, Lynnette
Pereira, Alberto M
Petersenn, Stephan
Pivonello, Rosario
Raff, Hershel
Reincke, Martin
Salvatori, Roberto
Scaroni, Carla
Shimon, Ilan
Stratakis, Constantine A
Swearingen, Brooke
Tabarin, Antoine
Takahashi, Yutaka
Theodoropoulou, Marily
Tsagarakis, Stylianos
Valassi, Elena
Varlamov, Elena V
Vila, Greisa
Wass, John
Webb, Susan M
Zatelli, Maria C
Biller, Beverly M K
Publication date
2021-10-20Subject
Endocrinology
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Show full item recordAbstract
Cushing's disease requires accurate diagnosis, careful treatment selection, and long-term management to optimise patient outcomes. The Pituitary Society convened a consensus workshop comprising more than 50 academic researchers and clinical experts to discuss the application of recent evidence to clinical practice. In advance of the virtual meeting, data from 2015 to present about screening and diagnosis; surgery, medical, and radiation therapy; and disease-related and treatment-related complications of Cushing's disease summarised in recorded lectures were reviewed by all participants. During the meeting, concise summaries of the recorded lectures were presented, followed by small group breakout discussions. Consensus opinions from each group were collated into a draft document, which was reviewed and approved by all participants. Recommendations regarding use of laboratory tests, imaging, and treatment options are presented, along with algorithms for diagnosis of Cushing's syndrome and management of Cushing's disease. Topics considered most important to address in future research are also identified.Citation
Fleseriu M, Auchus R, Bancos I, Ben-Shlomo A, Bertherat J, Biermasz NR, Boguszewski CL, Bronstein MD, Buchfelder M, Carmichael JD, Casanueva FF, Castinetti F, Chanson P, Findling J, Gadelha M, Geer EB, Giustina A, Grossman A, Gurnell M, Ho K, Ioachimescu AG, Kaiser UB, Karavitaki N, Katznelson L, Kelly DF, Lacroix A, McCormack A, Melmed S, Molitch M, Mortini P, Newell-Price J, Nieman L, Pereira AM, Petersenn S, Pivonello R, Raff H, Reincke M, Salvatori R, Scaroni C, Shimon I, Stratakis CA, Swearingen B, Tabarin A, Takahashi Y, Theodoropoulou M, Tsagarakis S, Valassi E, Varlamov EV, Vila G, Wass J, Webb SM, Zatelli MC, Biller BMK. Consensus on diagnosis and management of Cushing's disease: a guideline update. Lancet Diabetes Endocrinol. 2021 Dec;9(12):847-875. doi: 10.1016/S2213-8587(21)00235-7. Epub 2021 Oct 20Type
ArticleAdditional Links
http://www.sciencedirect.com/science/journal/22138587PMID
34687601Publisher
The Lancet, Diabetes & Endocrinologyae974a485f413a2113503eed53cd6c53
10.1016/S2213-8587(21)00235-7