Cost-effectiveness of craniotomy versus decompressive craniectomy for UK patients with traumatic acute subdural haematoma.
Author
Pyne, SarahBarton, Garry
Turner, David
Mee, Harry
Gregson, Barbara A
Kolias, Angelos G
Turner, Carole
Adams, Hadie
Mohan, Midhun
Uff, Christopher
Hasan, Shumaila
Wilson, Mark
Bulters, Diederik Oliver
Zolnourian, Ardalan
McMahon, Catherine
Stovell, Matthew G
Al-Tamimi, Yahia
Thomson, Simon
Viaroli, Edoardo
Belli, Antonio
King, Andrew
Helmy, Adel E
Timofeev, Ivan
Menon, David
Hutchinson, Peter John
Publication date
2024-06-16Subject
Neurology
Metadata
Show full item recordAbstract
Objective: To estimate the cost-effectiveness of craniotomy, compared with decompressive craniectomy (DC) in UK patients undergoing evacuation of acute subdural haematoma (ASDH). Design: Economic evaluation undertaken using health resource use and outcome data from the 12-month multicentre, pragmatic, parallel-group, randomised, Randomised Evaluation of Surgery with Craniectomy for Patients Undergoing Evacuation-ASDH trial. Setting: UK secondary care. Participants: 248 UK patients undergoing surgery for traumatic ASDH were randomised to craniotomy (N=126) or DC (N=122). Interventions: Surgical evacuation via craniotomy (bone flap replaced) or DC (bone flap left out with a view to replace later: cranioplasty surgery). Main outcome measures: In the base-case analysis, costs were estimated from a National Health Service and Personal Social Services perspective. Outcomes were assessed via the quality-adjusted life-years (QALY) derived from the EuroQoL 5-Dimension 5-Level questionnaire (cost-utility analysis) and the Extended Glasgow Outcome Scale (GOSE) (cost-effectiveness analysis). Multiple imputation and regression analyses were conducted to estimate the mean incremental cost and effect of craniotomy compared with DC. The most cost-effective option was selected, irrespective of the level of statistical significance as is argued by economists. Results: In the cost-utility analysis, the mean incremental cost of craniotomy compared with DC was estimated to be -£5520 (95% CI -£18 060 to £7020) with a mean QALY gain of 0.093 (95% CI 0.029 to 0.156). In the cost-effectiveness analysis, the mean incremental cost was estimated to be -£4536 (95% CI -£17 374 to £8301) with an OR of 1.682 (95% CI 0.995 to 2.842) for a favourable outcome on the GOSE. Conclusions: In a UK population with traumatic ASDH, craniotomy was estimated to be cost-effective compared with DC: craniotomy was estimated to have a lower mean cost, higher mean QALY gain and higher probability of a more favourable outcome on the GOSE (though not all estimated differences between the two approaches were statistically significant). Ethics: Ethical approval for the trial was obtained from the North West-Haydock Research Ethics Committee in the UK on 17 July 2014 (14/NW/1076). Trial registration number: ISRCTN87370545.Citation
Pyne S, Barton G, Turner D, Mee H, Gregson BA, Kolias AG, Turner C, Adams H, Mohan M, Uff C, Hasan S, Wilson M, Bulters DO, Zolnourian A, McMahon C, Stovell MG, Al-Tamimi Y, Thomson S, Viaroli E, Belli A, King A, Helmy AE, Timofeev I, Menon D, Hutchinson PJ; RESCUE-ASDH trial collaborators. Cost-effectiveness of craniotomy versus decompressive craniectomy for UK patients with traumatic acute subdural haematoma. BMJ Open. 2024 Jun 16;14(6):e085084. doi: 10.1136/bmjopen-2024-085084.Type
ArticleOther
Additional Links
https://www.ncbi.nlm.nih.gov/pmc/journals/1609/PMID
38885989Journal
BMJ OpenPublisher
BMJ Publishing Groupae974a485f413a2113503eed53cd6c53
10.1136/bmjopen-2024-085084