Affiliation
University of Birmingham; Sandwell and West Birmingham NHS TrustPublication date
2021-09-28Subject
Orthopaedics
Metadata
Show full item recordAbstract
There is increasing interest in the development of bone repair materials for biomedical applications. Magnesium (Mg)-based alloys have a natural ability to biodegrade because they corrode in aqueous media; they are thus promising materials for orthopaedic device applications in that the need for a secondary surgical operation to remove the implant can be eliminated. Notably, Mg has superior biocompatibility because Mg is found in the human body in abundance. Moreover, Mg alloys have a low elastic modulus, close to that of natural bone, which limits stress shielding. However, there are still some challenges for Mg-based fracture fixation. The degradation of Mg alloys in biological fluids can be too rapid, resulting in a loss of mechanical integrity before complete healing of the bone fracture. In order to achieve an appropriate combination of bio-corrosion and mechanical performance, the microstructure needs to be tailored properly by appropriate alloy design, as well as the use of strengthening processes and manufacturing techniques. This review covers the evolution, current strategies and future perspectives of Mg-based orthopaedic implants.Citation
Lu Y, Deshmukh S, Jones I, Chiu YL. Biodegradable magnesium alloys for orthopaedic applications. Biomater Transl. 2021 Sep 28;2(3):214-235.Type
ArticleOther
PMID
35836650Journal
Biomaterials TranslationalPublisher
Chinese Medical Multimedia Pressae974a485f413a2113503eed53cd6c53
10.12336/biomatertransl.2021.03.005