Biological tissues and components, and synthetic substrates for conjunctival cell transplantation.
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Author
Makuloluwa, Aruni KHamill, Kevin J
Rauz, Saaeha
Bosworth, Lucy
Haneef, Atikah
Romano, Vito
Williams, Rachel L
Dartt, Darlene A
Kaye, Stephen B
Affiliation
University of Liverpool; University of Birmingham; Harvard Medical School; Sandwell and West Birmingham NHS TrustPublication date
2021-06-11Subject
Ophthalmology
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The conjunctiva is the largest component of the ocular surface. It can be damaged by various pathological processes leading to scarring, loss of tissue and dysfunction. Depending on the amount of damage, restoration of function may require a conjunctival graft. Numerous studies have investigated biological and synthetic substrates in the search for optimal conditions for the ex vivo culture of conjunctival epithelial cells that can be used as tissue grafts for transplantation. These substrates have advantages and disadvantages that are specific to the characteristics of each material; the development of an improved material remains a priority. This review is the second of a two-part review in The Ocular Surface. In the first review, the structure and function of the conjunctiva was evaluated with a focus on the extracellular matrix and the basement membrane, and biological and mechanical characteristics of the ideal substrate with recommendations for further studies. In this review the types of biological and synthetic substrates used for conjunctival transplantation are discussed including substrates based on the extracellular matrix. .Citation
Makuloluwa AK, Hamill KJ, Rauz S, Bosworth L, Haneef A, Romano V, Williams RL, Dartt DA, Kaye SB. Biological tissues and components, and synthetic substrates for conjunctival cell transplantation. Ocul Surf. 2021 Oct;22:15-26.Type
ArticleOther
PMID
34119712Journal
The Ocular SurfacePublisher
Elsevierae974a485f413a2113503eed53cd6c53
10.1016/j.jtos.2021.06.003