Predictors of the efficacy of his bundle pacing in patients with a prolonged PR interval: A stratified analysis of the HOPE-HF randomized controlled trial.

Keene, Daniel; Kaza, Nandita; Srinivasan, Divya; Ali, Nadine; Tanner, Mark; Foley, Paul; Chandrasekaran, Badri; Moore, Philip; Adhya, Shaumik; Qureshi, Norman; Muthumala, Amal; Lane, Rebecca; Rinaldi, Aldo; Agarwal, Sharad; Leyva, Francisco; Behar, Jonathan; Bassi, Sukh; Ng, Andre; Scott, Paul; Prasad, Rachana; Swinburn, Jon; Tomson, Joseph; Sethi, Amarjit; Shah, Jaymin; Lim, Phang Boon; Kyriacou, Andreas; Thomas, Dewi; Chuen, Jenny; Kamdar, Ravi; Kanagaratnam, Prapa; Mariveles, Myril; Johnson, Nicholas; Falaschetti, Emanuela; Howard, James P; Arnold, Ahran; Cleland, John G F; Francis, Darrel P; Whinnett, Zachary; Shun-Shin, Matthew

Abstract

The randomized, double-blind, placebo-controlled HOPE-HF trial assessed the benefit of atrio-ventricular (AV) delay optimization delivered using His bundle pacing. It recruited patients with left ventricular ejection fraction ≤40%, PR interval ≥200 ms, and baseline QRS ≤140 ms or right bundle branch block. Overall, there was no significant increase in peak oxygen uptake (VO2max) but there was significant improvement in heart failure specific quality of life. In this pre-specified secondary analysis, we evaluated the impact of baseline PR interval, echocardiographic E-A fusion, and the magnitude of acute high-precision haemodynamic response to pacing, on outcomes.

Citation

Keene D, Kaza N, Srinivasan D, Ali N, Tanner M, Foley P, Chandrasekaran B, Moore P, Adhya S, Qureshi N, Muthumala A, Lane R, Rinaldi A, Agarwal S, Leyva F, Behar J, Bassi S, Ng A, Scott P, Prasad R, Swinburn J, Tomson J, Sethi A, Shah J, Lim PB, Kyriacou A, Thomas D, Chuen J, Kamdar R, Kanagaratnam P, Mariveles M, Johnson N, Falaschetti E, Howard JP, Arnold A, Cleland JGF, Francis DP, Whinnett Z, Shun-Shin M. Predictors of the efficacy of His bundle pacing in patients with a prolonged PR interval: A stratified analysis of the HOPE-HF randomized controlled trial. Eur J Heart Fail. 2024 Jul 18. doi: 10.1002/ejhf.3367. Epub ahead of print.

Type

Article