The Clinical Features and Outcomes of Pseudocirrhosis in Breast Cancer.
Author
Phillips, EdwardSethi, Mantegh
Vasanthakumar, Surammiya
Sherpa, Gina
Johnston, Stephen
Parton, Marina
Kipps, Emma
Turner, Nicholas C
Foxton, Matthew
Okines, Alicia
Publication date
2024-08-12Subject
Oncology. Pathology.
Metadata
Show full item recordAbstract
Abstract Pseudocirrhosis is a diffuse nodularity of the liver that radiologically mimics cirrhosis but is a distinct pathological process. It is seen almost exclusively in patients with liver metastases and may represent a response to systemic treatment. Data on the risk factors for pseudocirrhosis and outcomes are limited. In total, 170 patients with a diagnosis of breast cancer and pseudocirrhosis in a 10-year period were identified and retrospectively analysed. Data were collected on baseline patient characteristics, treatments received, and outcomes. Median time between diagnosis of liver metastases and diagnosis of pseudocirrhosis was 17.1 months (range, 0-149 months). In total, 89.4% of patients received chemotherapy between their diagnosis of breast cancer liver metastases and their diagnosis of pseudocirrhosis, most commonly a taxane (74.7%) or capecitabine (67.1%), and the median treatment lines received was 3. Median OS from first diagnosis of pseudocirrhosis was 7.6 months (95% CI: 6.1-9.6 months) and was longer in patients with HER2+ disease at 16.7 months (95% CI: 6.4-32.9 months), which was statistically significant. In our study, pseudocirrhosis occurred in the presence of liver metastases and was associated with a poor prognosis. HER2+ patients with pseudocirrhosis had a better prognosis than other subtypes, but we did not identify other significant predictors of survival. Chemotherapy was not a prerequisite for pseudocirrhosis development, although the majority of patients had received at least one line of chemotherapy before pseudocirrhosis was diagnosed. Keywords: HER2; cirrhosis; liver; metastases; pseudocirrhosis.Citation
Phillips E, Sethi M, Vasanthakumar S, Sherpa G, Johnston S, Parton M, Kipps E, Turner NC, Foxton M, Okines A. The Clinical Features and Outcomes of Pseudocirrhosis in Breast Cancer. Cancers (Basel). 2024 Aug 12;16(16):2822. doi: 10.3390/cancers16162822. PMID: 39199595.Type
ArticlePMID
39199595Journal
CancersPublisher
MDPIae974a485f413a2113503eed53cd6c53
10.3390/cancers16162822