Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes
Author
Adaikalakoteswari, AntonysunilJayashri, Ramamurthy
Nithya Sukumar, Nithya
Venkataraman, Hema
Pradeepa, Rajendra
Gokulakrishnan, Kuppan
Anjana, Ranjit Mohan
McTernan, Philip G.
Tripathi, Gyanendra
Patel, Vinod
Kumar, Sudhesh
Mohan, Viswanathan
Saravanan, Ponnusamy
Affiliation
University of Warwick; Madras Diabetes Research Foundation, India; Dr Mohan’s Diabetes Specialities Centre, WHO Collaborating Centre for Non-communicable Diseases Prevention and Control & IDF Centre of Education, Gopalapuram, Chennai, India; George Eliot Hospital, Nuneaton; University Hospital Coventry and WarwickshirePublication date
2014-09-26Subject
Diabetes
Metadata
Show full item recordAbstract
Background: Metformin, a standard therapy in type 2 diabetes, reduces vitamin B12 levels. Studies linking low vitamin B12 levels and cardiovascular disease are equivocal and suggest improving B12 levels may help in primary prevention. The role of vitamin B12 deficiency on cardiovascular risk factors, especially in type 2 diabetes has not been explored. The aim of this study is to investigate whether vitamin B12 deficiency in type 2 diabetes patients is associated with cardiovascular risk factors in two different ethnic groups in UK and India. Methods: Type 2 diabetes patients from two secondary care diabetic centres (Europeans - UK and Indians - India) were studied. Serum vitamin B12, folate and biochemical parameters were measured. Results: The prevalence rates of vitamin B12 deficiency (<191 ng/L) were 27% and 12% in Europeans and Indians, respectively and higher in metformin treated type 2 diabetes patients. In linear regression analysis, after adjusting for all likely confounding factors, vitamin B12 independently associated with triglycerides in both the populations and cholesterol/HDL ratio in Indians. Logistic regression showed type 2 diabetes patients with vitamin B12 deficiency were at significantly higher odds of having coexisting coronary artery disease (CAD) in Europeans with similar but non-significant trend in Indians, after adjusting for all likely confounding factors. Conclusions: The prevalence of vitamin B12 deficiency is common in type 2 diabetes patients and is associated with adverse lipid parameters. Type 2 diabetes management guidelines should include the recommendation for regular testing for B12 levels, especially for those on metformin.Citation
Adaikalakoteswari A, Jayashri R, Sukumar N, Venkataraman H, Pradeepa R, Gokulakrishnan K, Anjana RM, McTernan PG, Tripathi G, Patel V, Kumar S, Mohan V, Saravanan P. Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes. Cardiovasc Diabetol. 2014 Sep 26;13:129. doi: 10.1186/s12933-014-0129-4.Type
ArticleAdditional Links
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc4189588/PMID
25283155Journal
Cardiovascular DiabetologyPublisher
BioMed Centralae974a485f413a2113503eed53cd6c53
10.1186/s12933-014-0129-4